Service rendering

The following services were provided in 2015:
The provision of scientific/technical service, advice and assistance to local Government, regional services, institutions, research groups and individuals.

Thesis examination

  • Prof. Kana served as an external examiner for a PhD dissertation submitted to the University of Kwazulu Natal.
  • Dr. Gordhan served as an external examiner an MSc dissertation submitted to the University of Stellenbosch
  • Prof. Warner served as external examiner of a PhD submitted to the University of KwaZulu-Natal.
  • Numerous external examinations were done by members of the SU node. These include examining PhD or MSc theses for UKZN, SU, WITS, UP etc. Details are not recorded.

Journal editing and reviews

  • Prof. Kana reviewed manuscripts for PLoS One, FEMS Microbiology Letters, mBIO, The FEBS Journal, FEMS Pathogens and Disease, Antimicrobial Agents and Chemotherapy, Infection, Genetics and Evolution, BMC Genomics, BMC Public Health, Scientific Reports, Biochimica et Biophysica Acta: General Subjects and PLoS Pathogens,
  • Prof. Mizrahi served on the Editorial Advisory Boards of Tuberculosis and Cellular Microbiology, and on the Editorial Boards of Current Opinion in Microbiology; Pathogens & Disease, and Emerging Microbes and Infection. She was also appointed to the Editorial Board of Cell Chemical Biology (formerly Chemistry & Biology). Prof. Warner served on the Editorial Board of PLoS One.
  • Members of the UCT node reviewed manuscripts submitted to the New England Journal of Medicine; Nature Genetics; Chemistry & Biology; PLoS Pathogens; PNAS; Antimicrobial Agents and Chemotherapy; mBio; Lancet Infectious Diseases; Scientific Reports; Genome Biology; Journal of Bacteriology; Current Microbiology; PLoS One; Future Medicinal Chemistry; Tuberculosis; FEMS Microbiology Letters; Environmental Monitoring and Assessment; and the International Journal of Infectious Diseases.
  • Most if not all senior members of the SU node review numerous manuscripts for international journals. Records are not kept, but journals include Nature Reviews, Lancet, Lancet Infectious Diseases, PLoS, J Antimicrobial Chemotherapy, J Mol Med, BMC, Tuberculosis, IJTLD, JID, J Biotech, IJMS, Indian Heart Journal, Cardiovasc. J SA, J Biotech, IJMS, Molecular Biology and Evolution, Journal of Infection in Developing Countries, Journal of Bacteriology, Journal of Medical Microbiology, American Journal of Respiratory Critical Care Medicine, Tuberculosis and Journal of Molecular Biology and Biotechnology.

 Expert Panel or Committee Membership

Expert Panel or Committee

Organisation

Term

Member/ Role

Expert Committee

MSF, GATB, WHO

2008-present

Prof. Walzl

Working Group on New Drugs

Stop TB Partnership

2008-present

Prof. Walzl

Internal Governance and an Institutional scientific advisory committee

SU

2014-present

Prof. Walzl

IMPAACT TB Scientific Committee

NIH IMPAACT

2012-present

Prof. Walzl

Research Committee of Faculty of Health Sciences

SU

2009-present

Profs. Walzl &. Warren

Biomarkers & Clinical Endpoints Workgroup of Critical Path to TB Drug Regimens

NIH

2011-present

Prof Walzl

Consortium for TB Biomarkers (CTB2)

DST

2015-present

Prof Walzl

Ethics Committee for Experimental Animal Research

SU

2008-present

Dr. Wiid

Committee for Postgraduate Education of Faculty of Health Sciences

SU

2008-present

Prof. Gey van Pittius

Centre for Infectious Diseases

SU

2008-present

Prof. Warren

Human Research Ethics Committee of the Faculty of Health Sciences

SU

2009-present

Prof. Gey van Pittius

J-Expert Job evaluation Panel

MRC

2010-present

Dr. Kinnear

Planning Committee of Annual Academic YearDay

Faculty of Medicine & Health Sciences, SU

2012-present

Dr. Kinnear (vice-chair)

Critical Path to Treatment Regimens

NIH/Gates Foundation

2013-present

Profs. van Helden & Warren

ReSeqTB Expert panel

FIND

2015-present

Prof. Warren

Human Research Ethics Committee of the Faculty of Health Sciences

SU

2015-present

Dr. Ronacher

NIH Grants Early Career Reviewer

Center for Scientific Review, NIH

2015-present

Dr. K Ronacher

United States Animal Health Association Scientific Advisory Subcommitte for TB

USA

2015-present

Prof. Miller

Chair of Wildlife TB Study Group of SA

SA

2015-present

Prof. Miller

North American Veterinary Advisor for Elephants, Rhinoceros, and Hippopotamus

Association of Zoos and Aquariums, USA

2015-present

Prof. Miller

Association of South African Women in Science and Engineering (SA WISE) Executive Commitee Member

SA WISE

2015-present

Tashnica Olivier

Invited consultant for Longleat Safari Park, Southampton, UK

UK

2015-present

Prof. Miller

Golden Key International Honour Society, Stellenbosch Chapter - Executive Committee Member

SU

2015-present

Ms. du Plessis

NRF review panel for Postdoctoral fellowships, Bioinformatics and environmental sciences

NRF

2015-present

Dr. Klopper

Biosafety and Environmental Ethics Committee, Stellenbosch University

SU

2015-present

Prof. Sampson

Human Research Ethics Committee Board (HREC1)

SU

2015-present

Dr. Werely.

Ambassador: South African National Tuberculosis Association (SANTA)

SANTA

2015-present

Ms. Pule

Vice-President: South African Association Women Graduates (SAAWG), WC Province Branch

SAAWG, WC Province Branch

2015-present

Ms. Pule

Association of South African Women in Science and Engineering (SA WISE) Executive Commitee Member

SA WISE

2015-present

Ms. Pule

Co-ordinator and Executive Committee Member of Science Stars Mentorship Programme (SSMP)

SA

2015-present

Ms. Pule

ReSeqTB Expert Panel

CPTR

2015-present

Prof. Warren

Diagnostics Panel

CPTR

2015-present

Prof. Warren

Stellenbosch University Sub-Committee C

SU

2015-present

Prof. Warren

Stellenbosch University Clinical Infectious Diseases Managment Committee

SU

2015-present

Prof. Warren

Stellenbosch University Animal Ethics Committee

SU

2015-present

Dr. Parsons

Discovery Expert Group

Gates Foundation

2014-Present

Prof. Mizrahi

Scientific Advisory Board

K-RITH

2014-present

Prof. Mizrahi

Scientific Advisory Committee of SDDC, a structure-guided drug discovery consortium

Structural Genomics Consortium, University of Toronto

2014-present

Prof. Mizrahi

Keystone Symposia Study Group

Keystone Symposia

2014-Present

Prof. Mizrahi

Visiting Scholars and Lecturers Fund Committee

UCT

2014-present

Prof. Mizrahi

Health & Safety Committee of the IDM

UCT

2014-present

Prof. Warner (Chair)

Hazardous Chemical Coordinator of MMRU

UCT

2014-present

Prof. Warner

Lead Academic in charge of the WBS Level 2 BSL III Lab of IDM

UCT

2014-present

Prof. Warner

Education and Equipment Task Teams

UCT

2014-present

Prof. Warner

Board

Sydney Brenner Institute for Molecular Biosciences

2014-present

Prof. Kana

Microscopy and Microanalysis Unit Board

WITS

2014-present

Prof. Kana

Working Group

Global Alliance for TB Drug Development

2014-present

Prof. Kana

University Research Council (URC)

WITS

2014-present

Prof. Kana

FRC Budget task group,

Faculty of Health Sciences, WITS

2014-present

Prof. Kana

Research Entity Forum

Faculty of Health Sciences, WITS

2014-present

Prof. Kana

Research Equipment Review Committee

Faculty of Health Sciences, WITS

2014-present

Prof. Kana

Advisory Board

Faculty of Health Sciences, WITS

2014-present

Prof. Kana

Imaging Committee, Wits University

Faculty of Health Sciences, WITS

2014-present

Prof. Kana

Faculty Research Council (FRC)

Faculty of Health Sciences, WITS

2014-present

Prof. Kana & Dr. Gordhan

Postdoctoral Review Committee

NRF

2014-present

Dr. Gordhan

FISS & TWAS Postdoctoral Fellowships Advisory Panel Meeting.

NRF

2015-present

Dr. Klopper

South African Society of Human Genetics

SA Society of Human Genetics

2015-present

Prof. Hoal

SA Society of Human Genetics

SA

2015-present

Prof. Hoal

National TB think Tank

UCT

2015-present

Prof. Mizrahi

Chaired the Executive Committee of IDM

IDM, UCT

2015-present

Prof. Mizrahi

Chaired the Membership Committee of IDM

IDM,UCT

2015-present

Prof. Mizrahi

Chaired the Faculty of Health Sciences Biosafety Committee.

UCT

2015-present

Prof. Warner

International Union of Tuberculosis and Lung Disease Conference.

UCT

2015-present

Profs. Mizrahi & Warner

Health & Safety Committee of the IDM

UCT

2015-present

Dr. Evans

Operations and Laboratory Management Committee of the IDM

UCT

2015-present

Dr. Mukherjee

Health Sciences Faculty Postgraduate Students Council (HSPSC).

UCT

2015-present

Ms. Koch & Ms. Ditse

SA-Swiss Joint Bilateral Grant Program

Wits

2015-present

Prof Kana

Scientific Advisory Committee

Cape Town HVTN Immunology lab

2015-present

Prof. Kana

Research Entity Review Task Task group

Faculty of Health Sciences, Wits

2015-present

Prof. Kana

URC major and minor Equipment Review Committees

Wits

2015-present

Prof. Kana

Examples of Research Funding Reviews

  • Prof. Mizrahi served as a reviewer of research and fellowship applications for the HHMI; the DBT-India/Wellcome Trust Alliance; and the Bill & Melinda Gates Foundation, and as reviewer for promotions at Johns Hopkins University, the Centre for Infectious Disease Research (Seattle); Harvard School of Public Health and the University of Zimbabwe. Prof. Warner served as reviewer for international funding organizations including the Wellcome Trust (UK), the MRC (UK), and DFF-Mobilex (Denmark). He was also a reviewer for major South African funding organizations (NRF, MRC) and the various programmes they administer, including competitive funding for un/rated researchers, and MRC self-initiated research grants, and NRF student funding applications. In addition, he served as an internal reviewer for numerous research proposals considered by the IDM Research Committee, the Human Research Ethics Committee, and the Faculty Biosafety Committee.
  • Members of the CBTBR Wits node reviewed for the NHLS Research Trust, Biotechnology and Biological Sciences Research Council (BBSRC, UK), South African Medical Research Council (Newton Fund, SIR and various other programs), National Research Foundation (Rating and Evaluation Program and Competitive Grants).
  • Many of the SU node members are either on editorial boards or act as regular reviewers for many journals. A list is not provided, since we have so many of these we do not keep record.

Beneficiation of other researchers by CBTBR

  • The SU node also provides infrastructure and intellectual support to groups, even some who are not TB researchers and are therefore defined to be completely outside the CBTBR. For example, the lab housing our CBTBR genetics group also hosts a small group (n=7) of lab researchers, working on the Genetics of Psychiatric Disorders, part of the NRF SARChI research of Prof Soraya Seedat. It also houses a small SU group (Prof Soraya Bardien, n=9) working on the genetics of Parkinsons disease in South Africans. Reserachers from other institutions (Prof eg. K Dheda and his team) also utilise our facilities. Other researchers within SU, such as numerous persons from Paediatrics, Medical Microbiology and Immunology also use our facilities and know how. Our BL3 lab has approximately 70 registered users, of whom about 50 are part of our CBTBR node.
  • The UCT node is an integral component of the Institute of Infectious Disease and Molecular Medicine) and a major contributor to the institute’s shared research capacity and infrastructure, which is of direct benefit to all member groups involved in TB research. This includes a shared BSL3 laboratory, in which the UCT node has invested considerable resource. This laboratory serves the needs of 45 registered users from across the IDM, 10 of whom belong to the UCT node. The UCT node also provides extensive technical support and assistance in all aspects of mycobacteriology to staff, students and postdocs from the groups of three SARChI chairs, the Clinical Infectious Disease Research Initiative (CIDRI), the SA TB Vaccine Initiative (SATVI), the Desmond Tutu HIV Centre and the Division of Medical Microbiology. The UCT node also provided all of the TB biology expertise and support for the TB drug discovery projects conducted by the H3D Drug Discovery and Development Centre. However, the only outputs reported herein from the UCT node are those funded directly by the NRF grant to the CoE and resulting from the research and training programmes led by the two Team Members in this node, Prof. Valerie Mizrahi and Prof. Digby Warner, and Scientific Staff member, Dr. Joanna Evans.    

Other services rendered

  • Speciation of Non Tuberculous Mycobacteria (NTM) for Kruger National Park
  • Genotyping of clinical isolates (RFLP/mutation detection) for the NHLS, MSF and City Health.
  • Prof V Corfield was NRF rating panel moderator in 2015
  • Specialist diagnostic service for MDR or XDR TB cases for NHLS, Port Elizabeth.
  • Genetic and phenotypic analysis of discordant INH resistant/susceptible isolates from NHLS Port Elizabeth.
  • Specialist diagnostic service MDR or XDR TB cases, Brooklyn Chest Hospital, Cape Town.
  • Prof. Miller continues to receive and respond to requests for information from South African wildlife veterinarians in private industry, SANParks, EKZN Wildlife, DAFF, National Zoological Gardens, and wildlife researchers. This extends to Namibia, Zimbabwe, and Malawi. 
  • Hospital medical specialist clinical services, e.g. pulmonology and genetics
  • Vakzine Project Management (VPM): phase IIa vaccine trial on tuberculosis
  • IDRI- ID93 phase I vaccine trial
  • Aeras: C041 biobanking vaccine trial

6. Gender impact of research

Four out of the 13 Core Team Members of the CBTBR are women. In 2015, the CBTBR has also maintained a high percentage of female students (59% of all students and 48% of postdoctoral fellows), which is in line with demographic norms for the Life and Health Sciences at a national level. All three nodes have demonstrated that they are able to provide an environment which is attractive to, and supportive of women researchers at all levels, from Honours students to senior postdoctoral fellows and Team Members, as evidenced by the career progression of Drs. Mohube Maepa (nee Mowa), Katharina Ronacher                (promoted to Associate Professor on 6 April 2016) , Monique Williams, Marlo Moller and Lizma Streicher, who have developed into independent investigators and are raising their own grants. Drs Nelita du Plessis, Leanie Kleynhans, Joanna Evans, and others including Dr. Zanele Ditse, Zela Martin and Dr. Anastasia Koch are up-and-coming potential star researchers. At the Wits node, Drs Julian Peters and Melissa Chengalroyen are on a steep upward trajectory in their research careers. In addition, two students from the Wits node Ms. Nicole Narrandes and Ms. Zaahida Sheik Ismail have earned notable recoginition and awards for their research. These developments confirm that the CBTBR serves as a centre in which women researchers are nurtured and developed. Furthermore, as mentioned before, 2/3 SARCHis involved with the Centre are female professors. The SUN node has also recently appointed a new BL3 manager, also a female staff member (Dr N Allie).  


Service rendering

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© CBTBR 2006 | Last updated: 23 June, 2016