Research Outputs for 2011

* The Names in bold are CBTBR staff

Books / Chapters in Books (Total: 4)

  • *Muller B, Warren, RM, Williams M, Bottger EC, Gey van Pittius NC, Victor TC. 2011. Acquisition, transmission and amplification of drug-resistant tuberculosis. In: Antituberculosis chemotherapy. Progress in Respiratory Research, volume 40, Karger, pp. 96–104.
  • Donald PR, van Helden PD. Progress in Respiratory Research – Vol 40, Antituberculosis Chemotherapy. Edited by Peter R Donald, and Paul D van Helden. Published by S Karger AG, Basel, Switzerland, 2011. ISBN 978-3805-596275.
  • Williams M, Müller B, Uys P, Victor TC, Warren RM, Gey van Pittius NC. (2011) Tuberculosis Recurrence: Exogenous or Endogenous? In: Antituberculosis chemotherapy. Progress in Respiratory Research, volume 40, Karger, pp 73-80.
  • Diacon AH, Maritz JS, Donald PR. (2011) Early bactericidal activity of antituberculosis agents. In: Antituberculosis chemotherapy. Progress in Respiratory Research, volume 40, Karger, pp 213-219.

Articles in Peer-Reviewed Journals (Total: 47)

  • Scott LE, Gous N, Cunningham BE, Kana BD, Perovic O, Erasmus L, Coetzee G, Koornhof H, Stevens W. 2011. Dried Culture Spots for Xpert MTB/RIF External Quality Assessment: Results of phase 1 pilot study from South Africa. J Clin Microbiol. 49:4356-4360. [IF=4.220]
  • Kondratieva T, Rubakova E, Kana BD, Biketov S, Potapov V, Kaprelyants A, Apt A. 2011. Mycobacterium tuberculosis attenuated by multiple deletions of rpf genes effectively protects mice against TB infection. Tuberculosis (Edinb) 91:219-223. [IF=2.650]
  • Ahmadou Ahidjo B, Kuhnert D, McKenzie J, Machowski EE, Gordhan BG, Arcus VL, Abrahams GL, Mizrahi V. 2011. VapC toxins from Mycobacterium tuberculosis are ribonucleases that inhibit mycobacterial growth and are neutralized by cognate VapB antitoxins. PLoS ONE6:e21738. [IF=4.411]
  • Warner DF, Mizrahi V. 2011. Making Ends Meet in Mycobacteria. Mol. Microbiol. 79:283-287. [MicroCommentary] [IF=4. 819]
  • Williams MJ, Kana BD, Mizrahi V. 2011. Functional analysis of molybdopterin biosynthesis in mycobacteria identifies a novel fused molybdopterin synthase in Mycobacterium tuberculosis. J. Bacteriol. 193:98-106. [IF=3.726]
  • Adams LA, Möller M, Nebel A, Schreiber S, Van der Merwe L, Van Helden PD, Hoal EG. (2011) Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. Eur J Hum Genet. 19: 676-681. [IF=4.380]
  • Berg S, Garcia-Pelayo MC, Müller B, Hailu E, Asiimwe B, Kremer K, Dale J, Boniotti MB, Rodriguez S, Hilty M, Rigouts L, Firdessa R, Machado A, Mucavele C, Ngandolo BNR, Bruchfeld J, Boschiroli L, Muller A, Sahraoui N, Pacciarini M, Cadmus S, Joloba M, Van Soolingen D, Michel AL, Djonne B, Aranaz A, Zingsstag J, Van Helden P, Prtaels F, Kazwala R, Kallenius G, Hewinson RG, Aseffa A, Gordon SV, Smith NH. (2011) African 2, a clonal complex in Mycobacteruim bovis epidemiologically important in East Africa. Journal of Bacteriology. 193(3): 670-678. [IF=3.726]
  • Carugati M, Zanini F, Schiroli C, Gori A, Franzetti F, Hanekom M, Van der Spuy GD, Gey van Pittius NC, McEvoy CR, Ndabambi SL, Victor TC, Hoal EG, van Helden PD, Warren RM. (2011) Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Analysis and Beijing/W Family of Mycobacterium tuberculosis. J Clin Microbiol. 49(7): 2780-2781. . [IF=4.220]
  • Chegou NN, Hoek KG, Kriel M, Warren RM, Victor TC, Walzl G.(2011) Tuberculosis assays: past, present and future. Expert Rev Anti Infect Ther. 4: 457-469. [IF=3.090]
  • De Souza GA, Arntzen MO, Fortuin S, Schürch AC, Malen H, McEvoy CR,  Van Soolingen D, Thiede B, Warren RM, Wiker HG. (2011) Proteogenomic analysis of polymorphisms and gene annotation divergences in prokaryotes using a clustered mass spectrometry-friendly database. Mol & Cell Proteomics. 10: 10.1074/mcp.M110.002527 1-10. [IF=8.354]
  • De Wit E, Van der Merwe L, Van Helden PD, Hoal EG. (2011) Gene-gene interaction between tuberculosis candidate genes in a South African population. Mammalian Genome. 22: 100-110. [IF=2.771]
  • Diacon AH, Dawson R, Hanekom M, Narunsky K, Venter A, Hittel N, Geiter LJ, Wells CD, Paccaly AJ, Donald PR. (2011) Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int J Tuberc Lung Dis. 15(7): 949-54. [IF=2.557]
  • Donald PR, Maritz JS, Diacon AH. (2011) The pharmacokinetics and pharmacodynamics of rifampicin in adults and children in relation to the dosage recommended for children. Tuberculosis. 91: 196-207. [IF=2.650]
  • Friedrich SO, Venter A, Kayigire XA, Dawson R, Donald PR, Diacon AH. (2011) Suitability of Xpert MTB/RIF and Genotype MTBDRplus for patient selection for a tuberculosis clinical trial. J Clin Micro. 49(8): 2827-2831. [IF=4.220]
  • Govender L, Abel B, Hughes EJ, Scriba TJ, Kagina BM, De Kock M, Walzl G, Black G, Rosenkrands I, Hussey GD, Mahomed H, Andersen P, Hanekom WA. (2011) Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease. Vaccine. 29(1): 51-57. [IF=3.572]
  • Hanekom M, Gey van Pittius NC, McEvoy C, Victor TC, Van Helden PD, Warren RM. (2011) Mycobacterium tuberculosis Beijing genotype: A template for success. Tuberculosis. 91: 510-523. [IF=2.650]
    Hans RH, Wiid IJF, Van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. (2011) Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorganic & Medicinal Chemistrly Letters. 21: 2055-2058. [IF=2.661]
  • Hoek KGP, Van Rie A, Van Helden PD, Warren RM, Victor TC. (2011) Detecting Drug Resistant Tuberculosis: The Importance of Rapid Testing. Molecular Diagnosis & Therapy. 15(4): 189-194. [IF=2.561]
  • Honeyborne I, McHugh TD, Phillips PPJ, Bannoo S, Bateson A, Carroll N, Perrin FM, Ronacher K, Wright L, van Helden PD, Walzl G, Gillespie SH. (2011) Molecular Bacterial Load Assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment. J Clin Micro. 49(11): 3905-3911. [IF=4.220]
  • Jacobson KR, Theron D, Victor TC, Streicher EM, Warren RM, Murray MB. (2011) Treatment Outcomes of Isoniazid-Resistant Tuberculosis Patients, Western Cape Province, South Africa. Clinical Infectious Diseases. 53(4): 369-372. [IF=8.186]
  • Jacobsen M, Repsilber D, Kleinsteuber K, Gutschmidt A, Schommer-Leitner S, Black G, Walzl G, Kaufmann SHE. (2011) Suppressor of cytokine signaling-3 is affected in T cells from TuberculosisTB patients. Clin Microbiol Infect. 17(9): 1323-1331. [IF=4.784]
  • Jeon CY, Calver AD, Victor TC, Warren RM, Shin SS, Murray MB. (2011) Use of fluoroquinolone antibiotics leads to tuberculosis treatment delay in a South African gold mining community. Int J Tuberc Lung Dis. 15(1): 77-83. [IF=2.557]
  • Kleynhans L, Du Plessis N, Black GF, Loxton AG, Kidd M, Van Helden PD, Walzl G, Ronacher K. (2011) Medroxyprogesterone acetate alters Mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users. Plos ONE. 6(9): e24639. [IF=4.411]
  • Laisse CJM, Gavier-Widén D, Ramis G, Bila CG, Machado A, Quereda JJ, Ågren EO, Van Helden PD. (2011) Characterization of tuberculous lesions in naturally infected African buffalo (Syncerus caffer). J Vet Diagn Invest. 23(5): 1022-1027. [IF=1.381]
  • Ligthelm LJ, Nicol MP, Hoek KGP, Jacobson R, Van Helden PD , Marais BJ, Warren RM,  Wright CA. (2011) Xpert® MTB/RIF for the rapid diagnosis of tuberculous lymphadenitis from Fine Needle Aspiration biopsy specimens. J Clin Micro. 49(11): 3967-3970. [IF=4.220]
  • Louw GE, Warren RM, Gey van Pittius NC, Leon R, Jimenez A, Hernandez-Pando R, McEvoy CRE, Grobbelaar M, Murray M, Van Helden PD, Victor TC. (2011) Rifampicin reduces susceptibility to Ofloxacin in Rifampicin-resistant Mycobacterium tuberculosis through efflux. Am J Respir Crit Care Med. 184: 269-276. [IF=10.191]
  • Maertzdorf J, Repsilber D, Parida SK, Stanley K, Roberts T, Black G, Walzl G, Kaufmann SH. (2011) Human gene expression profiles of susceptibility and resistance in tuberculosis. Genes Immun. 12:15-22. [IF=4.637]
  • Matthews K, Wilkinson KA, Kalsdorf B, Roberts T, Diacon A, Walzl G, Wolske J, Ntsekhe M, Syed F, Russel J, Mayosi BM, Dawson R, Dheda K, Wilkinson RJ, Hanekom WA, Scriba TJ. (2011). Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. Tuberculosis. 91(6): 587-593. [IF=2.650]
  • Mestre O, Luo T, Dos Vultos T, Kremer K, Murray A, Namouchi A, Jackson C, Rauzier J, Bifani P, Warren RM, Rasolofo V, Mei J, Gao Q, Gicquel B. (2011) Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from polymorphisms in genes involved in DNA replication, recombination and repair. Plos ONE. 6(1): e16020. [IF=4.411]
  • Mkhize-Kwitshana ZL, Taylor M, Jooste P, Mabaso ML, Walzl G. (2011) The influence of different helminth infection phenotypes on immune responses against HIV in co-infected adults in South Africa. BMC Infect Dis. 11(1): 273. [IF=2.825]
  • Müller B, De Klerk-Lorist L-M, Henton MM, Lane E, Parsons SDC, Gey van Pittius NC, Kotze A, Van Helden PD, Tanner M. (2011) Mixed infections of Corynebacterium pseudotuberculosis and non-tuberculous mycobacteria in South African antelopes presenting with tuberculosis-like lesions. Vet Micro. 147: 340-345. [IF=3.256]
  • Müller B, Streicher EM, Hoek KGP, Tait M, Trollip A, Bosman ME,  Coetzee GJ, Chabula-Nxiweni EM, Hoosain E, Gey van Pittius NC, Victor TC, Van Helden PD, Warren RM. (2011) inhA promoter mutations: a gateway to extensively drug-resistant tuberculosis in South Africa? Int J Tuberc Lung Dis. 15(3): 344-351. [IF=2.557]
  • Nachega JB, Rosenkranz B, Simon G, Chaisson RE, Diacon AH, Taljaard JJ. (2011) Management of adult active tuberculosis disease in era of HIV pandemic, current practices and future perspectives. Infect Disord Drug Targets. 11(2): 134-143. [IF=3.061]
  • Onajole OK, Sosibo S, Govender P, Govender T, Van Helden PD, Maguire GEM, Mlinarić-Majerski K, Wiid IJF, Kruger HG. (2011) Novel linear diamine disubstituted polycyclic "cage" derivatives as potential anti-mycobacterial candidates. Chem Biol Drug Des. 78: 1022-1030. [IF=2.527]
  • Parsons SDC, Cooper D, McCall AJ, McCall WA, Streicher EM, Le Maitre NC, Müller A, Gey van Pittius NC, Warren RM, Van Helden PD. (2011) Modification of the QuantiFERON-TB Gold (In-Tube) assay for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer). Veterinary Immunology and Immunopathology. 142: 113-118. [IF=2.176]
  • Schürch AC, Kremer K, Warren RM, Hung NV, Zhao Y, Wan K, Boeree MJ, Siezen RJ, Smith NH, Van Soolingen D. (2011) Mutations in the regulatory network that underlie the recent clonal expansion of a dominant subclone of the Mycobcterium tuberculosis Beijing genotype. Infection, Genetics and Evolution. 11: 587-597. [IF=3.086]
  • Schürch AC, Kremer K, Hendriks ACA, Freyee B, McEvoy CRE, Van Crevel R, Boeree MJ, Van Helden PD, Warren RM, Siezen RJ, Van Soolingen D. (2011) SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes. PLoS ONE. 6(12): e28365. [IF=4.411]
  • Shanaube K, Hargreaves J, Fielding K, Schaap A, Lawrence K-A, Hensen B, Sismanidis C, Menezes A, Beyers N, Ayles H, Godfrey-Faussett P. (2011) Risk Factors Associated with Positive QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests Results in Zambia and South Africa. PLoS ONE 6(4): e18206. [IF=4.411]
  • Smith NH, Berg S, Dale J, Allen A, Rodriguez S, Romero B, Matos F, Ghebremichael S, Karoui C, Donati C, Machado AC, Mucavele C, Kazwala RR, Hilty M, Cadmus S, Ngandolo BNR, Habtamu M, Oloya J, Muller A, Milian-Suazo F, Andrievskaia O, Projahn M, Barandiarán S, Macías A, Müller B, Zanini MS, Ikuta CY, Rodriguez CAR, Pinheiro SR, Figueroa A, Cho S-N, Mosavari N, Chuang P-C, Jou R, Zinsstag J, Van Soolingen D, Costello E, Aseffa A, Proaño-Perez F, Portaels F, Rigouts L, Cataldi AA, Collins DM, Boschiroli ML, Hewinson RG, Ferreira Neto JS, Surujballi O, Tadyon K, Botelho A, Zárraga AM, Buller N, Skuce R, Michel A, Aranaz A, Gordon SV, Jeon B-Y, Källenius G, Niemann S, Boniotti MB, Van Helden PD, Harris B, Zumárraga MJ, Kremer K. (2011) European 1: A globally important clonal complex of Mycobacterium bovis. Infection, Genetics and Evolution. 11: 1340-1351. [IF=3.086]
  • Tadokera R, Meintjies G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, Chegou NN, Maartens G, Rangaka MX, Rebe K, Walzl G, Wilkinson RJ. (2010) Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome. Eur Resp J. 37 (5): 1248-1259. [IF=5.922]
  • Thee S, Seddon JA, Donald PR, Seifart HI, Werely CJ, Hesseling AC, Rosenkrantz B, Roll S, Magdorf K, Schaaf HS. (2011) Pharmacokinetics of isoniazid, rifampicin and pyrazinamide in children younger than two years of age with tuberculosis: evidence for implementation of revised world health organization recommendations. Antimicrobial Agents and Chemotherapy. 55(12): 5560-5567. [IF=4.672]
  • Theron G, Peter J, Van Zyl-Smit R, Mishra H, Streicher E, Murray S, Dawson R, Whitelaw A, Hoelscher M, Sharma S, Pai M, Warren R, Dheda K. (2011) Evaluation of the Xpert MTB/Rif Assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. Am J Respir Crit Care Med. 184: 132-140. [IF=10.191]
  • Van der Spuy DA, Cader S, Van der Spuy GD, Westwood AT. (2011) Improving nutritional status of children with cystic fibrosis at Red Cross War Memorial Children's Hospital. J Paediatr Child Health. 47: 282-286. [IF=1.122]
  • Van Wyk AC, Marais BJ, Warren RM, Van Wyk SS, Wright CA. The use of light-emitting diode fluorescence to diagnose mycobacterial lymphadenitis in fine-needle aspirates from children. Int J Tuberc Lung Dis. 15(1): 56-60. [IF=2.557]
  • Visser ME, Grewal HM, Swart EC, Dhansay MA, Walzl G, Swanevelder S, Lombard C, Maartens G. (2011) The effect of vitamin A and zinc supplementation on treatment outcomes in pulmonary tuberculosis: a randomized controlled trial. Am J Clin Nutr. 93(1): 93-100. [IF=6.606]
  • Walzl G, Ronacher K, Hanekom W, Scriba TJ, Zumla A. (2011) Immunological biomarkers of Tuberculosis. Nature Rev Immunol. 11(5): 343-354. [IF=35.196]
  • Warren RM, Hoek K, Sirgel F, Tait M, Gey van Pittius NC, Müller B, Streicher EM, Victor TC, Van Helden PD. (2011) Emergence and treatment of drug resistant tuberculosis: A comedy of errors. South African Respiratory J. 16(4): 112-116. [IF=Not Available]

Non Peer-Reviewed Articles (Total: 4)

  • Van Helden PD. (2011) Adaptation, redundancy or resilience. EMBO Reports. 12(9): 872.
  • Van Helden PD. (2011) Algorithms and surrogate markers in translational research. EMBO Reports. 12(12): 1206.
  • Van Helden PD. (2011) Treasure our rarities. EMBO Reports. 12(7): 611.
  • Van Helden PD. (2011) Water. EMBO Reports. 12(1): 2.

Published Abstracts (Total: 0)

Technical Reports (Total: 0)

Products / Artefacts / Patents (Total: 0)

Conferences/Meetings Attended & Invited Talks/Seminars Presented (Total: 69)

  • Kana B. Mycobacterial heterogeneity in TB Infection - Extreme makeover for the cell wall. Howard Hughes Medical Institute Early Career Scientist Competition. Janelia Farm Research Campus, Ashburn, Virginia, USA, 7 November.
  • Kana B. Mycobacterial heterogeneity in TB Infection - Extreme makeover for the cell wall. Invited Plenary Lecture. MRC Research Day, MRC Conference Centre, Parow, Cape Town, 19-20 October.
  • Kana B. Remodelling the mycobacterial cell wall for better TB drugs. Invited oral presention. 4th Federation of Infectious Diseases Societies of Southern Africa, Durban, 8-11 September.
  • Beukes G, Mapela L, Kana B. The role of resuscitation promoting factors in peptidoglycan hydrolysis and reactivation from dormancy in Mycobacterium smegmatis. Oral Presentation. MRC Research Day, MRC Conference Centre, Parrow, Cape Town, 19-20 October.
  • Narrandes N, Mizrahi V., Kana B. Functional characterization of molybdopterin synthase encoding genes in mycobacteria. Oral Presentation. MRC Research Day, MRC Conference Centre, Parow, Cape Town, 19-20 October.
  • Gordhan B. The role of DNA glycosylases in mutagenesis and adaptation to stress in mycobacteria. Oral Presentation. MRC Research Day, MRC Conference Centre, Parrow, Cape Town, 19-20 October.
  • Williams M, Kana B, Mizrahi V. Phenotypic characterization of ∆mobA mutants of Mycobacterium tuberculosis and Mycobacterium smegmatis. Talk presented at the South African Society of Microbiology (SASM) Conference, Cape Town, 6-9 November 2011.
  • Mizrahi V. New tools for tuberculosis drug discovery: the development of novel screening strains of M. tuberculosis and application in target-based approaches. Invited lecture presented at the CIDRI and Imperial College Wellcome Centre for Clinical Tropical Medicine Joint Annual Meeting, University of Cape Town, 12-14 March 2011.
  • Abrahams GL, Savvi S, Kumar A, Hung A, Ciulli A, Sherman DR, Barry CE III, Boshoff HIM, Mizrahi V. The development of novel screening Strains of M. tuberculosis for use in target-led approaches to tuberculosis drug discovery. Plenary lecture delivered at the Eighth International Conference on the Pathogenesis of Mycobacterial Infections, Saltsjöbaden, Sweden, 29 June – 3 July, 2011.
  • Mizrahi V. The development of novel screening strains of M. tuberculosis for use in target-led approaches to tuberculosis drug discovery. Plenary lecture delivered at the K-RITH Groundbreaking Symposium, Durban, 13-14 July 2011.
  • Gopinath K, Mizrahi V, Warner DF. Identification of genes required for vitamin B12 transport in M. tuberculosis.  Oral presentation delivered at the Fourth Postgraduate Research Day, Faculty of Health Sciences, University of Cape Town.  7 September 2011.
  • Warner DF. Mycobacterial metabolism and human disease. Plenary lecture presented at the FIDSSA Congress, Durban, South Africa, 8-11 September 2011.
  • Gopinath K, Mizrahi, V., and Warner, D.F. Identification of genes required for vitamin B12 transport in M. tuberculosis. UCT Postdoctoral Retreat, Cape Town, 12 -13 September 2011.
  • Walzl G. Biomarkers for different forms of tuberculosis. Keystone Symposia. Vancouver, Canada. 16-20 January 2011 (Co-organiser and speaker at conference)
  • Hoal EG. Association of toll-like receptor 1, 2, 4, 8 and 9 genes with susceptibility to pulmonary tuberculosis. Invited talk presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Warren RM. Stellenbosch University, South Africa: New molecular epidemiology insights of tuberculosis in Southern Africa. Invited talk presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Le Roex N. Host genetics and disease susceptibility. Invited talk presented at WOTRO Midterm Symposium. Utrecht, Netherlands, 27-29 June 2011.
  • Victor TC. High infection pressure: implications on the TB epidemic in South Africa. Invited talk presented at the University of Antwerp, Belgium, 23rd September 2011.
  • Essone P, Kalsdorf B, Chegou NN, Loxton A, Kriel D, Schöllhorn V, Ernst M, Lange C, and Walzl G. Bifunctional T-cell derived cytokines allow for discrimination between latent and active tuberculosis. Invited talk presented at the ERS meeting during September 2011 in Amsterdam.
  • Warren RM. Characterizing Drug-Resistant Epidemics in South Africa. Invited talk presented at the Center for Communicable Disease Dynamics 2nd Annual Symposium. Boston, USA. 3-4 October 2011.
  • Walz G. Biomarkers of treatment response. Chronic Lung Disease Conference, Cape Town. November 2011.
  • Van Helden PD. Progress in TB vaccine development for humans and animals. Invited talk presented at the 30th World Veterinary Congress 2011. Cape Town International Convention Centre, Cape Town, South Africa. 10-14 October 2011.
  • Van Helden PD. Burden of disease from a medical perspective. Invited talk presented at the Coloquium on Zoonoses and neglected infectious diseases of Africa. Johannesburg, South Africa. 1-4 November 2011.
  • Van Helden PD. Diagnostic Development. Invited talk presented at the Coloquium on Zoonoses and neglected infectious diseases of Africa. Johannesburg, South Africa. 1
  • Van Helden PD. The African tuberculosis situation including Mycobacteria outside the TB complex species. Invited talk presented at the 46th Annual Meeting of The American Society for Veterinary Clinical Pathology. Nashville, Tennessee, USA, 3
  • Warren RM. Seminar presented on Drug-resistant TB for World TB Day. Youngsfield Military Base, Cape Town, 24 March 2011.
  • Warren RM. Emergence of Drug resistant Tuberculosis: A comedy of errors. Invited talk presented at the 4th FIDSSA Congress. Durban, South Africa, 8-11 September 2011.
  • Willemse D, Williams MJ, Victor TC. Regulation of efflux in rifampicin resistant mutants of Mycobacterium tuberculosis. Invited talk presented at the 55th Annual Faculty of Health Sciences Academic Year Day. Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Corfield V. Promoting women in science across cultures:  the contribution of science centers. Talk presented at the 6th Science Centre World Congress. Cape Town, South Africa, September 2011.
  • Corfield V. “Science and Society” be squeezed into a one-size-fits-all Science Centre experience? Talk presented at the 6th Science Centre World Congress. Cape Town, South Africa, September 2011.
  • Mapela L, Beukes G, Gordhan B, Kana B. Resuscitation promoting factors in bacterial growth, peptidoglycan remodelling and muropeptide production. Poster presentation. Gordon Research Conference on TB Drug Development. Il Ciocco Hotel and Resort, Lucca (Barga), Italy, 3-8 July.
  • Chengalroyen M, Kana B. The role of resuscitation promoting factor in the reactivation of Mycobacterium tuberculosis in sputum. Poster Presentation. MRC Research Day, MRC Conference Centre, Parow, Cape Town, 19-20 October.
  • Chengalroyen M, Kana B. The role of resuscitation promoting factor in the reactivation of Mycobacterium tuberculosis in sputum. Poster Presentation. Wits Molecular Biosciences Research Thrust Symposium, 7 December.
  • Williams M, Kana B, Mizrahi V. Analysis of molybdopterin cofactor biosynthetic genes in mycobateria. Poster presented at the Keystone Symposium on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4), Vancouver, Canada, January 5-20, 2011
  • Ndwandwe DE, Venclovas C, Mizrahi V, Warner DF A novel mutasome in Mycobacterium tuberculosis. Poster presented at Keystone Symposiun on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics. Vancouver, Canada, January 15 - 20, 2011.
  • Ndwandwe DE, Venclovas C, Mizrahi, V, Warner, DF A novel mutasome in Mycobacterium tuberculosis. Poster presented at Fifth Annual New England TB Symposium on Vaccine Development: from Basic Research to Clinical Trials.  June 23, 2011. Broad Institute, Cambridge, USA.
  • Williams M, Kana BD, Mizrahi V. Phenotypic characterization of ∆mobA mutants of Mycobacterium tuberculosis and Mycobacterium smegmatis. Poster presented at the MRC Research Conference, Cape Town, 21 October 2011.
  • Moosa A, Mizrahi V, Warner D F. A Mycobacterium-specific protein family member required for vitamin B12 biosynthesis in M. tuberculosis. Poster presented at Keystone Symposiun on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics. Vancouver, Canada, January 15 - 20, 2011.
  • Koch A, Mizrahi V, Warner DF. The physiological implications of drug resistance mutations in mycobacteria. Poster presented at the 4th Postgraduate Research Day, Faculty of Health Sciences, University of Cape Town, 7 September 2011.
  • Naran K, Fenner C, Harrison STL, Mizrahi V, Warner DF. Characterization of the Antimycobacterial Effect of a Pseudomonas-Derived Activity. Poster presented at the 4th Postgraduate Research Day, Faculty of Health Sciences, University of Cape Town, 7 September 2011.
  • Naran K, Fenner C, Harrison STL, Mizrahi V, Warner DF. Characterization of the Antimycobacterial Effect of a Pseudomonas-Derived Activity. Poster presented at the South African Society of Microbiology (SASM) Conference, Cape Town, 6-9 November 2011.
  • Kleynhans L, Walzl G, Ronacher K. Medroxyprogesterone acetate alters mycobacterium bovis BCG induced cytokine expression in vitro and in PBMCS of contraceptive users. Poster presented at Tuberculosis:  Immunology, Cell Biology and Novel Vaccination Strategies (Keystone meeting), Faimont Hotel, Vancouver, British Columbia, Canada, 15-20 January 2011.
  • Macingwana L. Investigation of a synergistic effect of Sulfamethoxazole and Trimethoprim in combination with first-line TB drugs as potential first-line combination drug regime against Mycobacterium tuberculosis. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Victor T.  XDR-TB is evolving towards TDR-TB in the Eastern Cape, South Africa. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Gey van Pittius NC. A metabolomics approach to exploring the function of the ESX-3 type VII secretion system of M. smegmatis. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Louw GE. Rifampicin reduces susceptibility to ofloxacin in rifampicin resistant Mycobacterium tuberculosis through efflux. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Parsons S. Adaptation pf the QuantiFERON-TB gold (in tube) assay for the diagnoses of bovine tuberculosis in African buffaloes (Syncerus caffer). Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • van der Merwe R. The isolation, characterization and comparative genomics of novel South African mycobacteriophages from soil samples. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Wiid I. Elucidation of the physiological roles of Glutamine synthesas and Glutamate dehydrogenase in Mycobacterium smegmatis. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Svenson S. Differential activation of macrophages and dendritic cells by MDR and Non-MDR Mycobacterium tuberculosis strains. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Källenius G. Beijing Mycobacterium tuberculosis genotype is emerging in Mozambique in association with HIV co-infection. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Källenius G. Interferon inducible protein-10 (IP10) as a marker for Mycobacterium tuberculosis infection. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Källenius G. Mycobacterium tuberculosis strains causing the TB epidemic in Sweden a century ago. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Källenius G. A protective role for CD103+ lung dendritic cells during pulmonary tuberculosis.  Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Källenius G. Bystander effects of mycobacteria-infected macrophages on dendritic cells and their ability to mediate HIV-1 trans-infection. Poster presented at the 8th International Conference on the Pathogenesis of Mycobacterial Infections. Stockholm, Sweden, 30 June – 3 July 2011.
  • Möller M, Adams LA, Nebel A, Schreiber S, van der Merwe L, van Helden PD, Hoal EG. Polymorphisms in MC3R promoter and CTSZ 3`UTR are associated with tuberculosis susceptibility. Poster presented at the 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, Montréal, Canada, 11-15 October 2011.
  • Möller M, Quintana-Murci L, de Wit E, Delport W, Harmant C, Rugamika CE, Meintjes A, Balanovsky O, Zaporozhchenko V, Bormans C, van Helden PD, Seoighe C, Behar DM, Hoal EG. The History in our Genes: the Complex Structure of the South African Coloured Population. Poster presented at the Joint International Conference of the African and Southern Africa Societies of Human Genetics, Cape Town, South Africa, 6-9 March 2011.
  • Salie M, Möller M, Duh F-M, Martin MP, Hoal EG, Carrington M. The role of killer cell immunoglobulin-like receptors and their human leukocyte antigen class-I ligands in susceptibility to tuberculosis. Poster presented at the Joint International Conference of the African and Southern African Societies of Human Genetics. Cape Town, South Africa, 6-9 March 2011.
  • Le Roex N. Solid SNPs in Syncerus: Novel SNP detection in African buffalo. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Ehlers L, Chegou NN, Walzl G, van Helden PD, Ronacher K. Effect of TB Treatment on Metabolic Hormone Profiles. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Möller M, Adams LA, Nebel A, Schreiber S, van der Merwe L, van Helden PD, Hoal EG. Polymorphisms in MC3R promoter and CTSZ 3`UTR are associated with tuberculosis susceptibility. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Siame KK. A phylogenomic and Proteomic Investigation into the Evolution and Biological Characteristics of the Principal Genetic Group 1 Members of Mycobacterium tuberculosis. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Steyn NL. Stellenbosch University, South Africa. Investigating the localization of ESX-3 secretion system components in Mycobacterium smegmatis. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Van der Merwe C. An investigation into the role of mitochondrial dysfunction in Parkinson's disease. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Wagman C, Möller M, van der Merwe L, Hoal EG. Investigating single nucleotide polymorphisms and interactions of candidate genes involved in susceptibility to tuberculosis in a South African population. Poster presented at the 55th Annual Faculty of Health Sciences Academic Year Day, Stellenbosch University, Cape Town, South Africa, 17-18 August 2011.
  • Corfield V. Catalysing partnerships: can science centres bridge the gap and promote dialogue between scientists and the public in biomedicine? Poster presented at the 6th Science Centre World Congress. Cape Town, South Africa, September 2011.
  • Corfield V. SA WISE: South African sisters in science and engineering network with science centres. Poster presented at the 6th Science Centre World Congress. Cape Town, South Africa, September 2011.
  • Ehlers L. Effect of TB Treatment on Metabolic Hormone Profiles. Poster presented at the Medical Research Council Research Day. Cape Town, South Africa, 19-20 October 2011.
  • Willemse D, Victor TC, Williams MJ. Regulation of efflux in rifampicin resistant mutants of Mycobacterium tuberculosis. Poster presented at the Medical Research Council Research Day. Cape Town, South Africa, 19-20 October 2011.

Other Relevant Outputs (including honours and awards to staff)

  1. In October 2011, Dr. Bavesh Kana from the Wits node was invited to give the opening plenary lecture at the MRC Research Day, held at the MRC Conference Centre in Parrow. Dr. Kana’s lecture was attended by all participants of the Research Day, the acting president of the MRC and some members from the MRC Board. Dr. Kana was invited on the basis of being an MRC Career Awardee.
  2. Dr. Kana from the Wits node received a renewal for his MRC Career Development Award. This was based on a competitive renewal process for this program and provides a further two years of funding to the Wits node.
  3. Dr. Bhavna Gordhan from the Wits node was selected to give oral presentations at two local conferences/meetings as testimony to the high quality of their research.
  4. Prof. Mizrahi was invited to London for an interview under the auspices of the Exchanges at the Frontier program of the UK-based Wellcome Collection. The interview, which took place at the Wellcome Collection on 21 October 2011. An abridged version of the interview was broadcast by BBC World on 9 Dec 2011 to an estimated audience of 40-50 million listeners worldwide. The podcast is available online and can be downloaded from http://www.bbc.co.uk/podcasts/series/discovery
  5. Dr. Digby Warner was the overall winner of the prestigious 2011 BioVision-Lilly Award in conjunction with the Academy of Sciences for the Developing World (TWAS). The award recognises young researchers from developing countries for outstanding scientific achievements in tuberculosis-related research. The winners were announced at a special ceremony at the 7th Biovision World Life Sciences Forum
  6. Dr. Digby Warner awarded a K-RITH Collaborative Travel Award.
  7. Prof. Mizrahi was appointed to the Editorial Board of the international journal, Emerging Microbes & Infection
  8. Dr. Digby Warner was appointed as an Associate Member of the IIDMM
  9. Gey van Pittius, NC was elected as a member of the Academy of Science of South Africa (ASSAf)
  10. Hoal, EG. Obtained a B2 rating by the NRF (2011)
  11. Walzl G. Invited to the AERAS vaccine research workshop
  12. Walzl G. Workgroup member of Endpoints and Biomarker Working Groups of the Critical Path to New TB Drug Regimens
  13. Walzl G. A member of the core writing team of the International Roadmap for Tuberculosis Research
 

Research


© CBTBR 2006 | Last updated: 17 August, 2015