Publications 2009

Books / Chapters in Books (Total: 2)

  • Kana BD, Machowski EE, Rubin H, Mizrahi V. (2009) Electron transport and respiration. In: Mycobacterium: Genomics and Molecular Biology (Parish T & Brown A, eds.) Horizon Press, ch. 3, pp. 35-64.
  • McEvoy CRE, Warren RM, van Helden PD. 2009. Molecular Methods and Their Application in TB Epidemiology. In: Schaaf HS, Zumla AI (ed.) Tuberculosis. A Comprehensive Clinical Reference. Elsevier Publications. pp 28 – 37.

Articles in Peer-Reviewed Journals (Total: 41)

  • Mowa MB, Warner DF, Kaplan G, Kana BD, Mizrahi V. (2009) Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria. J Bacteriol. 191(3):985-995. (IF=3.636)
  • Kana BD, Bonazzi M, Calzavara-Silva CE. (2009) The molecular and cellular basis of infection - perspectives from the first advanced summer school in Africa. IUBMB Life 61:85-90. (IF=2.364)
  • Abdallah AM, Verboom T, Weerdenburg E, Gey van Pittius NC, Mahasha PW, Jiménez C, Parra M, Cadieux N, Brennan MJ, Appelmelk BJ, Bitter W. (2009) PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5, Mol. Microbiol.73(3):329–340. (IF=5.213)
  • Bezuidenhout J, Roberts T, Muller L, van Helden P, Walzl G.(2009) Pleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomas. PLoS ONE. 4(1):e4228. (IF unavailable)
  • Bitter W, Houben ENG, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao L-Y, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, Brosch R. (2009) Systematic genetic nomenclature for type VII secretion systems, PLoS Pathogens Oct;5(10):e1000507 (IF=9.125)
  • Black GF, Thiel BA, Ota M, Parida SK, Adegbola R, Boom WH, Dockrell HM, Franken KLMC, Friggen AH, Hill PC, Klein MR, Lalor MK, Mayanja H, Schoolnik G, Stanley K, Weldingh K, Kaufmann SHE, Walzl G, Ottenhoff THM, The GCGH Biomarkers for TB Consortium. (2009) Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clin Vaccine Immunol. 16(8):1203-1212. (IF=2.237)
  • Chaoui I, Sabouni R, Kourout M, Jordaan AM, Lahlou O, Elouad R, Akrim M, Victor TC, Elmzibri M. (2009) Analysis of Isoniazid, Streptomycin and Ethambutol resistance in Mycobacterium tuberculosis isolates from Morocco. J. Infect. Dev. Ctries. 2009; 3(4):278-284. (IF unavailable)
  • Chegou NN, Black GF, Kidd M, van Helden PD, Walzl G. (2009) Host markers in Quantiferon supernatants differentiate active TB from latent TB infection: preliminary report. BMC Pulmonary Medicine. 9:21. (IF unavailable)
  • Cobat A, Gallant CJ, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Jaïs JP, Boland-Auge A, van Helden P, Casanova JL, Abel L, Hoal EG, Schurr E, Alcaïs A. (2009) Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis. J Exp Med. 206(12):2583-2591. (IF=15.219)
  • Detjen AK, Loebenberg L, Grewal HM, Stanley K, Gutschmidt A, Kruger C, Du PN, Kidd M, Beyers N, Walzl G, Hesseling AC. (2009) Short-term Reproducibility of a Commercial Interferon-gamma Release Assay. Clin. Vaccine Immunol. 16(8):1170-1175. (IF=2.237)
  • Diacon AH, Pym A, Grobusch M, Patientia R, Rustomjee R, Page-Shipp L, Pistorius C, Krause R, Bogoshi M, Churchyard G, Venter A, Allen J, Palomino JC, De Marez T, van Heeswijk RPG, Lounis N, Meyvisch P, Verbeeck J, Parys W, de Beule K, Andries K, Mc Neeley DF. (2009) The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. New Engl. J. Med. 360(23):2397-2405. (IF=50.017)
  • Djoba Siawaya JF, Beyers, N, van Helden PD, Walzl G. (2009) Differential Cytokine Secretion and Early Treatment Response in Patients with Pulmonary Tuberculosis. Clin. Exp. Immunol. 156(1):69-77. (IF=2.853)
  • Djoba Siawaya JF, Chegou N, Van Den Heuvel MM, Diacon AH, Beyers N, Van Helden PD, Walzl G.(2009) Differential cytokinee/chemokines and kl-6 profiles in patients with different forms of tuberculosis. Cytokine 47(2):132-136. (IF=2.214)
  • Donald PR, van Helden PD. (2009) The Global Burden of Tuberculosis - Combating Drug Resistance in Difficult Times. New Engl. J. Med. 360(23):2393-2395. (IF=50.017)
  • Espie IW, Hlokwe TM, Gey van Pittius NC, Lane E, Tordiffe ASW, Michel AL, Müller A, Kotze A, and van Helden PD. (2009) A case of pulmonary infection due to Mycobacterium bovis in a Black Rhinoceros (Diceros bicornis minor) in South Africa. J. Wildlife Dis. 45(4):1187-1193 (IF=1.330)
  • Hayward D, van Helden PD, Wiid I. (2009) Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation. BMC Evolution. Biol. 9:48. (IF=4.050)
  • Hesseling AC, Mandalakas AM, Kirchner LH, Chegou NN, Marais BJ, Zhu X, Black GF, Stanley K, Beyers N, Walzl G. (2009) Highly Discordant T-Cell Responses In Individuals With Recent Household Tuberculosis Exposure. Thorax 64(10):840-846. (IF=7.069)
  • Hoek KG, Schaaf HS, Gey van Pittius NC, van Helden PD, Warren RM. (2009) Resistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment. S. Afr. Med. J. 99(11), 785-787. (IF unavailable)
  • Kagina BM, Abel B, Bowmaker M, Scriba TJ, Gelderbloem S, Smit E, Erasmus M, Nene N, Walzl G, Black G, Hussey GD, Hesseling AC, Hanekom WA. (2009) Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response. Vaccine.  27(40): 5488-5495. (IF=3.298)
  • Louw GE, Warren RM, Gey van Pittius NC, McEvoy CR, Van Helden PD, Victor TC. (2009) A balancing act: Efflux/influx in mycobacterial drug resistance, Antimicrob. Agents Ch. 53(8):3181-3189. (IF=4.716)
  • Louw GE, Warren RM, van Helden PD, Victor TC. (2009) Rv2629 191A/C nucleotide change is not associated with RIF resistance in Mycobacterium tuberculosis. Clin. Chem. Lab. Med. 47(4):500-501. (IF=1.888)
  • Marais BJ, Hesseling AC, Schaaf HS, Gie RP, van Helden PD, Warren RM. (2009) Mycobacterium tuberculosis transmission is not related to household genotype in a highly endemic setting. J. Clin. Microbiol. 74(5):1338-1343. (IF=3.945)
  • Marcotty T, Matthys F, Godfroid J, Rigouts L, Ameni G, Gey van Pittius NC, Kazwala R, Muma J, Van Helden PD, Walravens K, De Klerk LM, Geoghegan C, Mbotha D, Otte M, Amenu K, Abu Samra N, Botha C, Ekron M, Jenkins A, Jori F, Kriek N, McCrindle C, Michel A, Morar D, Roger F, Thys E, and Van den Bossche P. (2009) Zoonotic tuberculosis and brucellosis in Africa: neglected zoonoses or minor public health issues? Ann. Trop. Med. Parasit. 103(5):401-411. (IF=1.652)
  • McEvoy CRE, van Helden PD, Warren RM, Gey van Pittius NC. Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region. BMC Evolution. Biol. 9:237. (IF=4.050)
  • McEvoy CRE, Warren RM, van Helden PD, Gey van Pittius NC. (2009) Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes. Tuberculosis 89:439-442. (IF=1.758)
  • McIlleron H, Willemse M, Werely CJ, Hussey GD, Schaaf HS, Smith PJ, Donald PR. (2009) Isoniazid Plasma Concentrations in a Cohort of South African Children with Tuberculosis: Implications for International Pediatric Dosing Guidelines. Clin. Infect. Dis. 48(11):1547-1553. (IF=8.266)
  • Michel AL, Coetzee ML, Keet DF, Mare L, Warren RM, Cooper D, Bengis RG, Kremer K, van Helden PD. (2009) Molecular epidemiology of Mycobacterium bovis isolates from free ranging wildlife in South African game reserves. Vet. Microbiol. 133: 335–343. (IF=2.370)
  • Möller M, Nebel A, Valentonyte R, van Helden P, Schreiber S, Hoal E. (2009)  Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population. Tuberculosis 89:189-194. (IF=1.758)
  • Müller B, Hilty M, Berg S, Garcia-Pelayo MC, Dale J, Boschiroli ML, Cadmus S, Naré B, Ngandolo R, Godreuil S, Diguimbaye-Djaibé C, Kazwala R, Bonfoh B, Njanpop-Lafourcade BM, Sahraoui N, Guetarni D, Aseffa A, Mekonnen MH, Razanamparany VR, Ramarokoto H, Djønne B, Oloya J, Machado A, Mucavele C, Skjerve E, Portaels F, Rigouts L, Michel A, Müller A, Källenius G, van Helden PD, Hewinson RG, Zinsstag J, Gordon SV, SmithNH. (2009) African 1; An Epidemiologically Important Clonal Complex of Mycobacterium bovis Dominant in Mali, Nigeria, Cameroon and Chad. J Bacteriol. 191(6):1951-1960. (IF=3.636)
  • Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB. (2009) Sensitive and specific polymorphism discovery in bacteria using massively parallel sequencing. Nature Methods. 6(1):67-69. (IF=13.651)
  • Onajole OK, Govender K, Govender P, van Helden PD, Kruger HG, Maguire GEM, Muthusamy K, Pillay M, Wiid I, Govender T. (2009) Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and Evaluation as potent anti-tuberculosis agents. Eur. J. Med. Chem. 4297–4305. (IF=2.882)
  • Parsons SD, Gous TA, de Villiers C, Warren RM, Seier JV, van Helden PD. (2009) Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON-TB Gold (In-Tube Method) assay. J. Med Primatol 38:411-417.  (IF=1.047)
  • Schaaf HS, Victor TC, Venter A, Brittle W, Hesseling AC, Marais BJ, van Helden PD, Donald PR. (2009) Ethionamide cross- and co-resistance in children with isoniazid-resistant tuberculosis. Int. J. Tuberc. Lung. D. 13(11):1355-1359. (IF=2.304)
  • Uys PW, van Helden PD, Hargrove JW. (2009) Tuberculosis reinfection rate as a proportion of total infection rate correlates with the logarithm of the incidence rate – a mathematical model.  J Roy Soc Interface. 6(30):11-15. (IF=3.621)
  • Uys PW, Warren R, van Helden PD, Murray M, Victor TC. (2009) The Potential of Rapid Diagnosis for Controlling Drug-Susceptible and Drug-Resistant TB in High Prevalence Communities. J Clin Microbiol. 47(5):1484-1490. (IF=3.945)
  • Van der Spuy GD, Kremer K, Ndabambi SL, Beyers N, Dunbar R, Marais BJ, van Helden PD, Warren RM.  (2009) Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics. Tuberculosis. 89(2)120-125. (IF=1.758)
  • Van der Spuy GD, van Helden PD, Warren RM. (2009). Effect of study duration on the interpretation of tuberculosis molecular epidemiology investigations. Tuberculosis. 89:238-242. (IF=1.758)
  • Van der Spuy GD, Warren RM, van Helden PD. (2009) The role of molecular epidemiology in low-income, high-burden countries. Int.J.Tuberc.Lung Dis. 13:419-420. (IF=2.304)
  • Warren RM, Streicher EM, Gey van Pittius NC, Marais BJ, van der Spuy GD, Victor TC, Sirgel F, Donald PR, van Helden PD. (2009) The clinical relevance of Mycobacterial pharmacogenetics. Tuberculosis. 89(3):199-202. (IF=1.758)
  • Wright CA, Hesseling AC, Bamford C, Bergess SM, Warren RM, Marais BJ. (2009) Fine Needle Aspiration Biopsy-A first line diagnostic procedure in paediatric tuberculosis? Int. J. Tuberc. Lung. D. 13:1373-1379. (IF=2.304)
  • Wright CA, Warren RM, Marais BJ. (2009) Fine Needle Aspiration Biopsy-A (FNAB) – an undervalued diagnostic modality in paediatric mycobacterial disease. Int J Tuberc Lung D. 13:1467-1475. (IF=2.304)

Non Peer-Reviewed Articles (Total: 2)

  • Marais BJ, Parker SK, Verver S, Van Rie A, Warren RM. (2009) Primary and Postprimary or Reactivation Tuberculosis: Time to Revise Confusing Terminology? Am. J. Roentgenol. (Letter) 192:W10361-803X/019X1924-W1. (IF=2.940)
  • van der Spuy GD, Warren RM, van Helden PD. (2009) "The role of molecular epidemiology in low-income (high-burden) countries" (Editorial), Int. J. Tuberc Lung D.  13(4):419-420. (IF=2.304)

Published Abstracts (Total: 0)

Technical Reports (Total: 1)

  • IAEA (Int Atomic Energy Agency): SAF6008 Progress report on drug resistance project for SA (June 2009).

Products / Artefacts / Patents (Total: 0)

Conferences/Meetings Attended & Invited Talks/Seminars Presented (Total: 103)

  • Warner DF, Mowa MB, Machowski EE, Kaplan G, Kana BD, Mizrahi V. Novel and vulnerable pathways in DNA metabolism. Plenary lecture, Keystone Symposium on Tuberculosis: Biology, Pathology & Therapy, Keystone, CO, 25-30 January 2009.
  • Kana BD.  Resuscitation promoting factors in M. tuberculosis. Human Genetics Seminar Series, NHLS Braamfontein, 19 February 2009.
  • Warner DF. Physiology of M. tuberculosis – Chinks in the armour. Invited lecture, SATBAT conference on the Molecular Epidemiology of TB, Sunnyside Park Hotel, Johannesburg, 26-27 March 2009.
  • Mizrahi V. Survival, subversion and stress response strategies in Mycobacterium tuberculosis: Implication for Drug Discovery. Plenary lecture presented at the ESF Europe-Africa Frontier Research Conference on Infectious Diseases: From Basic to Translational Research, Cape Winelands, 4-9 April 2009.
  • Mizrahi V. Survival, subversion and stress response strategies of M. tuberculosis: Implications for TB drug discovery. Plenary lecture presented at the 109th General Meeting of the American Society for Microbiology, Philadelphia, 18-22 May 2009.
  • Kana BD. Resuscitation promoting factors in Mycobacterium tuberculosis. Lecture presented at the MRC TB Colloquium, Cape Town 3-4 June 2009.
  • Warner DF. Mycobacterium and mechanisms of mutagenesis. Lecture presented at the MRC TB Colloquium, Cape Town 3-4 June 2009.
  • Mizrahi V. Panel Member: TB, Where We Stand and Where We Can Go. Global Health Research Congress, Seattle, USA, 15-18 June 2009.
  • Kana BD, Gordhan BG, Downing KJ, Sung N, Vostroktunova G, Machowski EE, Tsenova L, Young M, Kaplreylants A, Kaplan G, Mizrahi V. Resuscitation promoting factors are required for the virulence of Mycobacterium tuberculosis but are collectively dispensable for growth in vitro. Invited talk presented at the Third Congress of European Microbiologists, hosted by the Federation of European Microbiological Societies (FEMS), Gothenberg, Sweden, 28 June – 2 July 2009.
  • Kana BD, Abrahams GL, Sung N, Warner DF, Gordhan BG, Machowski EE, Tsenova L, Sacchettini J, Stoker NG, Kaplan G, Mizrahi V. Role of the Y-family polymerase-encoding dinB homologues in Mycobacterium tuberculosis. Poster presented at the Third Congress of European Microbiologists, hosted by the Federation of European Microbiological Societies (FEMS), Gothenberg, Sweden, 28 June – 2 July 2009.
  • Moosa A, Mizrahi V, Warner DF. The metabolism of vitamin B12 in Mycobacterium tuberculosis: the role of pseudovitamin B12. Talk presented at the SATBAT Meeting, Lung Institute, UCT, 18 July 2009.
  • Williams M, Kana BD, Mizrahi V. Analysis of molybdopterin cofactor biosynthetic genes in mycobacteria. Invited talk presented at the 6th Gordon Research Conference on Molybdenum & Tungsten Enzymes, Lucca, Italy, 5-10 July 2009.
  • Gordhan BG. Improving the budget approval process for improved purchasing power and maintenance management. Invited talk presented a talk at the Intelligent Laboratory Management Conference, Rosebank, Johannesburg, 27 July 2009.
  • Warner DF. Transport and function of vitamin B12 in mycobacteria. Invited talk presented at the EPFL, Lausanne, Switzerland, 31 July 2009.
  • Moosa A, Mizrahi V, Warner DF. The metabolism of vitamin B12 in Mycobacterium tuberculosis: role of alternate B12 cofactors. Invited short talk presented at the Gordon Research Conference on Vitamin B12 and Corphins, 2-7 August 2009.
  • Mizrahi V. Target identification and validation. Invited talk presented at the CSIR/ICS-UNIDO Workshop on the Advanced Design and Development of Potential Drugs Against Tuberculosis. Pretoria, 3-5 August 2009.
  • Mizrahi V. Novel Tuberculosis Drug Target Identification and Validation. Haemolotogy & Molecular Medicine Seminar, University of the Witwatersrand, Johannesburg, 12 August 2009.
  • Abrahams GL, Mizrahi V. Target-based whole-cell screening. Talk presented at the Annual Meeting of the IMTB Consortium, Magdalen College, Oxford, 15-16 August 2009.
  • Kana BD.  Resuscitation-promoting factors in M. tuberculosis: Invited talk presented at the Imperial College of London, 24 August 2009.
  • Kana BD. Resuscitation-promoting factors in Mycobacterium tuberculosis - Wake Up TB. Invited talk presented at the MRC Career Awards Symposium, Medical Research Council, Cape Town, 19 October 2009.
  • Moosa A, Mizrahi V, Warner DF. Mechanisms of vitamin B12 transport and regulation in mycobacteria. Invited talk presented at the 2nd Postgraduate Cross-Faculty Symposium, University of the Witwatersrand, 20-21 October 2009. [Awarded Second prize in Science Faculty Oral Presentation category]
  • Abrahams GL, Mowa MB, Magwira C, Savvi S, Warner DF, Kana BD, Mizrahi V. Novel TB drug target identification and validation. Talk presented at Human Genetics Seminar Series, University of the Witwatersrand & NHLS, Johannesburg, 26 November 2009.
  • Mizrahi V. The DST/NRF Centre of Excellence for Biomedical TB Research. The Centres of Excellence Annual Function, STIAS, Stellenbosch, 26 November 2009.
  • Abrahams GL, Mowa MB, Magwira C, Savvi S, Warner DF, Kana BD, Mizrahi V. Novel TB drug target identification and validation. Invited talk presented at AstraZeneca India. Bangalore, India, 9 December 2009.
  • Warren RM. Laboratory Based Research at the Faculty of Health Sciences. Invited talk presented to the Harvard Delegation. Stellenbosch University. Stellenbosch. South Africa, January 2009
  • Walzl G. The possible implementation of Quantiferon TB by the Department of Health. Invited Talk at the National Department of Health / Pro-Gen Diagnostics Workshop. Johannesburg, South Africa, 02 March 2009.
  • McEvoy CRE, Cloete REA, Gey van Pittius NC. Mycobacterium tuberculosis PE and PPE gene family genetic polymorphisms: antigenic variation or evolution? Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Newton-Foot M, Steyn A, Sampson S, Warren RM, van Helden PD, Gey van Pittius NC. The M. tuberculosis ESX-3 secretion system interactome Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Warren RM. XDR-TB: a molecular epidemiological perspective. Invited talk at the World TB Day. 2 Military Hospital ,Cape Town, South Africa, 02 March 2009.
  • Warren RM. South African Molecular Epidemiological Data. Invited talk presented at the SATBAT Workshop - Promoting Innovative TB Research Through Training. Johannesburg, South Africa, 26 March 2009.
  • Hoal EG. Host genetic susceptibility to tuberculosis. Talk presented at European Science Foundation: Europe-Africa Frontier Research Conference, Infectious Diseases: From Basic to Translational Research. Somerset West, South Africa,  4-9 April 2009.
  • Hoal EG. Whole Genome Scans in Tuberculosis. Talk presented at 13th South African Society for Human Genetics Congress. Stellenbosch, South Africa, 7 April 2009.
  • van Helden PD. Science versus dogmas in combating the TB scourge. Invited talk presented at the Royal Society of South Africa meeting held in Cape Town, South Africa, 15 April 2009.
  • McEvoy CRE. Science in the media: opinions from a practicing scientist. Invited talk at the Stellenbosch university Honours journalism class. Stellenbosch, South Africa, 22 May 2009.
  • Gey van Pittius NC. Evolution, duplication and variation of the PE and PPE multigene families of Mycobacterium tuberculosis . Invited talk presented at the 109th General Meeting of the American Society for Microbiology (ASM)  Philadelphia, Pennsylvania, USA, 17-21 May 2009.
  • van Helden PD. Keynote Address presented at the MRC TB Colloquium. Cape Town, South Africa, 3-4 June 2009.
  • Victor TC. Mechanisms of drug-resistance. Talk presented at the MRC TB Colloquium. Cape Town, South Africa, 3-4 June 2009.
  • Warren RM. Genetic Epidemiology of TB in the Western Cape. Talk presented at the MRC TB Colloquium. Cape Town, South Africa, 3-4 June 2009.
  • Chegou NN. Differentiate active TB from Latent TB infection: preliminary report. Talk presented at the 2nd Global Symposium on Interferon Gamma Release Assays. Dubrovnik, Croatia, 30 May-01 June 2009.
  • van Helden PD. Molecular epidemiology: role for transmission of MDR/XDR.  Talk presented at the WHO Catalysing HIV/TB research: innovation, funding and networking meeting. Cape Town, South Africa, 18-19 July 2009.
  • Hoek KGP, Gey van Pittius NC, van Helden PD, Warren RM. Single closed tube detection of Drug-resistance in mycobacterium tuberculosis complex. Talk presented at the NIH ICORTA South Africa TB Aids Training Program meeting. Cape Town, South Africa, 18 July 2009.
  • Harper CJ, Hayward D, Wiid I, Van Helden PD. Elucidation Of The Physiological Roles Of Glutamine Synthetase And Glutamate Dehydrogenase In Mycobacterium Smegmatis. Talk presented at the 52nd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Salie M, Hoal EG, Möller M. An Investigation Of Purinergic P2x7 Receptor And Toll-Like Receptor 1 In Susceptibility To Human Pulmonary Tuberculosis. Talk presented at the 52nd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • McEvoy CRE. The Mycobacterium tuberculosis Genome: Insights into Evolution, Epidemiology and Phylogeography. Invited talk at the University of Cape Town Department of Molecular and Cellular Biology Seminar Series. Cape Town, South Africa, 14 August 2009.
  • Gey van Pittius N.C. Tuberculosis Research at the Faculty of Health Sciences of the University of Stellenbosch. Invited talk presented at the Centre for Aids Research (CFAR) Colorado Tuberculosis Workshop. Fort Collins, Colorado, USA, 09 September 2009.
  • McEvoy CRE. Extensive analysis of PE and PPE gene variation in Mycobacterium tuberculosis. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Warren RM. A label-free method identified differentially abundant proteins in related Mycobacterium tuberculosis Beijing genotype. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Warren RM. Adaptaion of Mycobacterium tuberculosis gene expression in response to the evolution of rifampicin-resistance. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Hanekom M. Increased bacterial load is associated with strains of the Mycobacterium tuberculosis Beijing genotype. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Hanekom M. Mixed Mycobacterium tuberculosis infection in patients resident in a high HIV prevalence setting. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Gey van Pittius NC. The evolution of genus Mycobacterium and variation in the M. tuberculosis complex. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Victor TC. Beijing genotype Mycobacterium tuberculosis strains drive the drug-resistant tuberculosis epidemic in the Western and Eastern Cape regions of Soth Africa. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Streicher EM. XDR-TB: Acquisition of ofloxacin Resistance during treatment. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Hoek KGP. Genotypic based diagnosis of drug-resistance in Mycobacterium tuberculosis complex and treatment implications. Invited talk at the TBadapt 3rd meeting on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resisitance. Cape Town, South Africa, 16-18 September 2009.
  • Van Helden PD. TB Transmission between Wild and domestic Animals in South Africa. Invited talk at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy held in San Francisco, California, USA,12-15 September 2009.
  • Van Helden PD. TB Transmission between Wild and domestic Animals in South Africa. Invited talk at the University of California, Berkeley, USA 17 September 2009.
  • Walzl G. Bio-signatures for TB: how close are we? Thaler lecture, Mini-Symposium on TB Biomarkers and Development of New Vaccines hosted by the Aeras Global TB Vaccine Initiative. Washington DC, USA, 21 September, 2009.
  • Van Helden PD. TB Genomics and TB/HIV in Africa. Invited talk presented at the Keystone Symposia on Overcoming the Crisis of TB and AIDS. Arusha, Tanzania, 20-25 October 2009.
  • Warren RM. Adaptation of Mycobacterium tuberculosis gene expression in response to the evolution of rifampicin-resistance. Invited talk presented at the TB Adapt Meeting, Stellenbosch. November 2009.
  • Warren RM. TB Adapt South Africa. Invited talk presented at the TB Adapt Meeting, Stellenbosch. November 2009.
  • van Helden PD. The DST/NRF Centre of Excellence for Biomedical TB Research. The Centres of Excellence Annual Function, STIAS, Stellenbosch, 26 November 2009.
  • Walzl G. How do complex cytokine patterns improve our understanding of protection against TB? South African Immunology Society Conference, Cape Town, South Africa, 9-11 December 2009.
  • Warren RM.  Molecular Epidemiology of drug resistant tuberculosis. Invited talk presented at the DAAD Summer School, Stellenbosch, South Africa, December 2009.
  • Gey van Pittius NC. The evolution of the genus Mycobacterium and virulence in the M. tuberculosis complex. Invited talk presented at the DAAD Summer School, Stellenbosch, South Africa, December 2009.
  • Moosa A, Mizrahi V, Warner DF. The metabolism of vitamin B12 in M. tuberculosis: the role of alternate B12 cofactors. Poster presented at the MRC TB Colloquium, Cape Town 3-4 June 2009.
  • Naran K, Mizrahi V, Warner DF. Characterisation of the antimycobacterial effect of a Pseudomonas-derived activity. Poster presented at the MRC TB Colloquium, Cape Town 3-4 June 2009.
  • Ndwandwe DE, Warner DF, Mizrahi V. Mechanisms of mutagenesis in M. tuberculosis: Structural and functional characterization of the polymerase accessory factors encoded by Rv3394c and Rv3395c. Poster presented at the MRC TB Colloquium, Cape Town 3-4 June 2009.
  • Naran K, Veale R, Mizrahi V, Warner DF. Characterization of the antimycobacterial effect of a Pseudomonas-derived activity. Poster presented at the 2nd Postgraduate Cross-Faculty Symposium, University of the Witwatersrand, 20-21 October 2009.
  • Ndwandwe DE, Venclovas Č, Mizrahi V, Warner DF. Mechanisms of mutagenesis in Mycobacterium tuberculosis: structural and functional characterization of the DNA polymerase accessory factors encoded by Rv3394c and Rv3395c. Poster presented at the 2nd Postgraduate Cross-Faculty Symposium, University of the Witwatersrand, 20-21 October 2009.
  • Bharuthram A, Mizrahi V, Gordhan BG. Construction and phenotypic characterization of M. smegmatis mutants deficient in DNA glycosylases. Poster presented at the 2nd Postgraduate Cross-Faculty Symposium, University of the Witwatersrand, 20-21 October 2009.
  • Mapela L, Kana BD. Characterization of resuscitation promoting factors in Mycobacterium smegmatis. Poster presented at the 2nd Postgraduate Cross-Faculty Symposium, University of the Witwatersrand, 20-21 October 2009.
  • Black GF, Loxton A, Ottenhoff TH, Haks M, Franken KLMC, Stanley K, Chegou N, Parida SK, Kaufmann SHE, Walzl G and the GC6-74 Consortium. Immunogenicity of novel M. tuberculosis antigens, cytokine profiles and gene expression patterns hold promise as markers of disease activity. Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Cliff J, Cho J-E, Whittaker J, van Helden P, Beyers N, Walzl G, Dockrell H. Identification of biomarkers to predict tuberculosis treatment outcome by transcriptomic analysis of peripheral blood. Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Govender L, Abel B. Hughes J, de Kock M, Choice T, Walzl G, Black G, Andersen P, Mohamed H, Hussey G, Hanekom W. Persons latently infected with M. tuberculosis have T cell responses to the novel antigens Rv2669 and Rv2660, whereas patients with active disease do not. Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Nene N, Walzl G, Ottenhoff T, Franken K, Stanley K, Parida SK, Kaufmann S, Black G. Immunity to tuberculous and non-tuberculous mycobacteria in adult TB contacts in the Western Cape. Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • McEvoy CRE, Cloete REA, Gey van Pittius NC, Mycobacterium tuberculosis PE and PPE gene family genetic polymorphisms: antigenic variation or evolution? Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Newton-Foot M, Steyn A, Sampson S, Warren RM., van Helden PD, Gey van Pittius NC, The M. tuberculosis ESX-3 secretion system interactome Poster presented at the Keystone Symposium on Tuberculosis: Biology, Pathology and Therapy, Keystone, USA, January 2009.
  • Hemmings SMJ, Tait M, Martin L, Aitken L, De Wit E, Black G, Hoal EG, Walzl G, Seedat S. Genetic markers associated with posttraumatic stress disorder in tuberculosis household contacts: a preliminary study. Biological Psychiatry Congress 2009, Arabella, Kleinmond.
  • Parsons SDC. Early detection of tuberculosis in chacma baboons (Papio ursinus) using the QuantiFERON-TB Gold assay. Poster presented at the International Meeting on Emerging Diseases. Vienna, Austria, 13-16 February 2009.
  • Chegou NN. Host markers in Quantiferon Supernatants differentiate active TB from Latent TB infection: preliminary report. Poster presented at the ESF Europe-Africa Frontier Research Conference on Infectious Diseases: From Basic to Translational Research. Cape Town, South Africa, 4-9 April 2009.
  • Fortuin S. Characterisation of Phosphoproteins in Mycobacterium tuberculosis. Poster presented at the ESF Europe-Africa Frontier Research Conference on Infectious Diseases: From Basic to Translational Research. Cape Town, South Africa, 4-9 April 2009.
  • Bester M, Warren RM, Johnson R, van Helden PD, Ndimba BK, Victor TC. Mechanisms that determine the level of rifampicin resistance in Mycobacterium tuberculosis. Poster presented at the MRC TB Colloquium. Cape Town, South Africa, 3-4 June 2009.
  • Hoek KGP, Gey van Pittius NC, van Helden PD, Warren RM. Single tube detection of ethambutol resistance in mycobacterium tuberculosis complex. Poster presented at the MRC TB Colloquium. Cape Town, South Africa, 3-4 June 2009.
  • Louw GE, Warren RM, Gey van Pittius NC, van Helden PD, Victor TC. New hope for treatment of drug resistant tuberculosis. Poster presented at the MRC TB Colloquium. Cape Town, South Africa, 3-4 June 2009.
  • Bruiners N, Gey van Pittius NC, Warren RM. Investigating the human M. tuberculosis interactome to identify the host targets of ESAT-6 and CFP-10. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Fang Z, Van Helden PD, Gey van Pittius NC. Elucidation of the substrates of mycosin 3, an essential protease of Mycobacterium tuberculosis. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Hoek KGP, Gey van Pittius NC, Van Helden PD, Warren RM. Single tube detection of ethambutol resistance in Mycobacterium tuberculosis complex. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Kruger C, Warren R, Gey van Pittius NC. Determining the incidence of non-tuberculous mycobacteria in environmental settings. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Louw GE, Warren RM, Gey van Pittius NC, Van Helden PD, New hope for treatment of drug resistant tuberculosis. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Newton-Foot M, Smit M, Gey van Pittius NC. The construction of genetic knockouts of the antigen secretion systems ESX-3 and -4 in Mycobacterium smegmatis. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009. 
  • Streicher EM, Warren RM, De Kock M, Bosman M, Gey van Pittius NC, Van Helden PD, Victor TC. Extensively drug-resistant tuberculosis (XDR-TB) in the Western Cape region of South Africa: acquisition vs transmission. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Van der Merwe RG, Gey van Pittius NC, Van Helden PD. Isolation and characterization of South African mycobacteriophages. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Hoek KGP, Schaaf HS, Gey van Pittius NC, Van Helden PD, Warren RM. Incidence of resistance to pyrazinamide and ethambutol compromises treatment regimens for MDR/XDR-TB treatment. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Mcevoy CRE, Van Helden PD, Warren RM, Gey Van Pittius NC. Rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Mlamla ZC, Louw GE, Warren R, Gey Van Pittius NC, Van Helden P, Victor T, Hoornenborg E, Taljaard JJ, Hoffmann R, Morkar J, Jordaan HF. Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Hanekom M, Van De Berg D, Streicher EM, Cox H, Mcdermid C, Victor TC, Van Helden PD, Warren RW. Mixed Mycobacterium Tuberculosis Infection In Patients Isolates Resident In A High Hiv Prevalence Setting. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Hayward D, Harper CJ, Wiid I, Van Helden PD. Differences In Glutamine/ Glutamate Metabolism May Influence Mycobacterial Survival. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Kleynhans L, Mcconnell A, Walzl G. The Impact Of The Steroid Hormones Medroxyprogesterone Acetate, Cortisol And Progesterone On Protective Immunity To Tuberculosis. Poster presented at the 53rd Academic Year Day, University of Stellenbosch, 12-13 August 2009.
  • Louw GE, Warren RM, Gey van Pittius NC, van Helden PD, Victor TC. New hope for treatment of drug resistant tuberculosis. Poster presented at the Keystone Symposia on Overcoming the Crisis of TB and AIDS. Arusha, Tanzania, 20-25 October 2009.
  • Streicher EM, Gey van Pittius NC, Bosman M, van Helden PD, Victor TC, Warren RM. Acquisition of ofloxacin Resistance during treatment of Multidrug-Resistant Tuberculosis. Poster presented at the Keystone Symposia on Overcoming the Crisis of TB and AIDS. Arusha, Tanzania, 20-25 October 2009.
  • Prach L, Kirby J, Schelle M, Warren RM, van Helden PD, Keasling J, Alber T. Structure and biosynthesis of novel diterpines in Mycobacterium tuberculosis. Poster presented at the Keystone Symposia on Overcoming the Crisis of TB and AIDS. Arusha, Tanzania, 20-25 October 2009.
  • Wangh LJ, Rice J, Rahman L, Kreisworth B, Kramer FR, Warren RM. Construction of a highly Multiplexed LATE-PCR Assay for M(X)Dr-TB. Poster presented at the Keystone Symposia on Overcoming the Crisis of TB and AIDS. Arusha, Tanzania, 20-25 October 2009.
  • Loxton A, Roberts T, Black G, Walzl G. Regulatory T-cells and high levels of FOXP3 mRNA leads to decreased immune responses in HIV-TB co-infection. Poster presented at the AIDS Vaccine 2009 Conference. Paris, France, 19-23 October 2009.

Conferences / Meetings Hosted (Total 2)

  • The Stellenbosch University node held an International TB conference focusing on the Effect of Genetic Variation in Mtb on Vaccine Escape and the Acquisition of Drug Resistance, at Lanzerac wine estate between the 16th and 18th of September 2009.
  • The Stellenbosch University node and the Desmond Tutu TB Centre held a workshop with colleagues from George Washington University, Debra Benator, Fred Gordin and Donna Conwell from 24 to 27 February 2009 to work on a joint strategy for a SU application to the CDC-sponsored TB Trials Consortium (TBTC). This collaborative effort brings together a strong group of adult and paediatric TB and HIV researchers at the faculty in a joint consortium called TB SUN. TB SUN will aim to join larger collaborative TBTC international activities to implement trials of new TB therapies where most needed, including in children.

Other Relevant Outputs (including honours and awards to staff)

  1. Mizrahi V. Elected into Fellowship of the American Academy of Microbiology in January 2009 and inaugurated into the Academy at a function that took place in Philadelphia during the General Meeting of the American Society for Microbiology. The Academy, the honorific leadership group within the American Society for Microbiology, recognizes excellence, originality, and creativity in the microbiological sciences, and election to fellowship is a mark of distinction.
  2. Mizrahi, V. Awarded an A2 rating by the NRF
  3. Mizrahi V. Appointed to a three-year term on the Scientific Advisory Committee of the Global Alliance for TB Drug Development, which is based in New York. She attended SAC meetings in New York in June and December.
  4. Kana B. Awarded a Career Development Award from the MRC. He is the second member of the Wits node to receive this honour
  5. Kana B. Stage 1 application for the Friedel Sellschop Award successful and invited to submit a proposal for an individual research grant to the URC. This is the premier award from Wits for young researchers.
  6. Kana, BD. Rated as C3 category researcher by the NRF
  7. Van Helden, PD. Academy of Science of South Africa’s (ASSAf) Science-for-Society Gold Medal
  8. Van Helden, PD. Featured in an article on Thompson Reuters’ Sciencewatch, citing him as the 4th highest ranked scientist in the World in the field of tuberculosis
  9. Gey van Pittius, NC. Innovation Fund - Patent Incentive Fund Award (2009)
  10. Gey van Pittius, NC. Health Sciences Faculty Award for Outstanding Research (June 2009)
  11. Gey van Pittius, NC. Rated as Y1 category researcher by the NRF
  12. Gordhan, BG. Rated as C2 category researcher by the NRF
  13. Warner, DF. Rates as Y1 category researcher by the NRF
  14. Walzl G. Received the Rector’s Award for Outstanding Research in 2009
  15. Warren, RM. Rated as B2 category researcher by the NRF

Research


© CBTBR 2006 | Last updated: 17 August, 2015