Publications 2006

Books / Chapters in Books

  • Warner DF, and Mizrahi V. 2006. M. tuberculosis Physiology. In: Tuberculosis Handbook, Vol. 1 (Kaufmann SHE & Rubin EJ, eds.), Wiley VCH. Submitted (invited book chapter).
  • Chihota VN, van Helden PD, Victor TC, and Warren RM. 2006. Molecular Epidemiology of Tuberculosis in South Africa:  Lessons learnt. In Molecular Epidemiology and Population Genetics of Tuberculosis, Eds. Academy of Science, Malaysia. pp 69-100.
  • van Helden PD, Moller M, Babb C, Warren RM, Walzl G, Uys P, and Hoal EG. 2006. TB epidemiology and Human Genetics. In Innate immunity to pulmonary infection. Wiley, Chichester (Novatis Foundation Symposium 279) pp 17-41.

Articles in peer-reviewed journals

Non peer-reviewed articles

Technical Reports

  • To IAEA ( Int Atomic Energy Agency): Report RAF/6.025-004:   Regional progress report on training, data Management and Quality assurance programmes on radionuclide based molecular techniques in the detection of drug resistant tuberculosis –  24 – 28 April 2006,  Addis Ababa, Ethiopia.
  • To IAEA ( Int Atomic Energy Agency): Final report RAF 6025: Isotopes for the control of drug resistant TB (Nairobi May 2006, 8 different African countries).

Products / Artifacts / Patents

  • Warren R, Gey van Pittius N, van Helden P. 2006 Single step method for the diagnosis and speciation of M tuberculosis, M africanum, M bovis and M bovis BCG. SA Provisional Patent 2006/00683.

Conferences / meetings attended

  • Gordhan, B.G. Effectively Managing the Waste Process - Handling, Storage, Transport and Disposal. Talk presented at Laboratory Management for Improved Performance conference, Park Hyatt, Johannesburg, 17-18 May 2006.
  • Mizrahi V. Chair/ Co-Organiser and Lab Head presenter, Workshop on Training in the TB Basic Sciences, Cape Town, 5-6 June 2006.
  • Dawes SS. CU-SA Fogarty AITRP Trainee feedback presentation, Workshop on Training in the TB Basic Sciences, Cape Town, 5-6 June 2006.
  • Kana, BD. CU-SA Fogarty AITRP Trainee feedback presentation, Workshop on Training in the TB Basic Sciences, Cape Town, 5-6 June 2006.
  • Mizrahi V. Beckman-Coulter Gold Medal Lecture, XXth Conference of the SA Society for Biochemistry and Molecular Biology, Pietermaritzburg, 2-5 July 2006
  • Gordhan BG, Smith DA, Kana BD, Bancroft G, Mizrahi, V. The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice. Talk presented at the XXth Conference of the SA Society for Biochemistry and Molecular Biology, Pietermaritzburg, 2-5 July 2006
  • Kana BD, Moon S, Warner DF, Gordhan BG, Machowski EE, Sacchettini J, Stoker NG, Kaplan G, Mizrahi V. Characterisation of Y-family DNA polymerases from Mycobacterium tuberculosis. Talk presented at the XXth Conference of the SA Society for Biochemistry and Molecular Biology, Pietermaritzburg, 2-5 July 2006
  • Mowa MB, Dawes SS, Mizrahi, V. Function of class Ic ribonucleotide reductase in Mycobacterium smegmatis. Poster presented at the XXth Conference of the SA Society for Biochemistry and Molecular Biology, Pietermaritzburg, 2-5 July, 2006
  • Savvi S, Mizrahi V, Dawes SS. Cobalamin dependent metabolic pathways and their contribution to virulence of Mycobacterium tuberculosis. Poster presented at the XXth Conference of the SA Society for Biochemistry and Molecular Biology, Pietermaritzburg, 2-5 July 2006
  • Warner DF, Machowski EE, Brackin R, Stoker NG, Boshoff HIM, Dawes SS, Mizrahi, V. Y-family polymerases in mycobacteria: roles in genetic adaptation and long-term survival. Invited talk presented at the 2006 Health Sciences Research Day, University of the Witwatersrand, 23 August, 2006. Winner: Best Oral Presentation Prize (Molecular and Cell Biology & Evolutionary Sciences section).
  • Warner DF, Savvi, S., Mizrahi, V., and Dawes, S.S. Vitamin B12-mediated inhibition of growth of Mycobacterium tuberculosis CDC1551. Poster presented at the Health Sciences Research Day, University of the Witwatersrand, 23 August 2006.
  • Mizrahi, V. The application of genetic tools to investigate molecular mechanisms of pathogenesis in Mycobacterium tuberculosis. Invited lecture presented at the EMBO/FEMS Spetsai Summer School on the Molecular Basis of Bacterial Virulence and Survival within Infected Hosts and in the Environment, Spetses, Greece, 4-15 September 2006
  • Mizrahi, V. Mechanisms of genetic adaptation in Mycobacterium tuberculosis: Implications for inter-strain variation and the evolution of drug resistance. Invited lecture presented at the EMBO/FEMS Spetsai Summer School on the Molecular Basis of Bacterial Virulence and Survival within Infected Hosts and in the Environment, Spetses, Greece, 4-15 September 2006
  • Warner DF, Machowski EE, Brackin R, Stoker NG, Boshoff HIM, Dawes SS, Mizrahi, V. Y family polymerases in mycobacteria: roles in genetic adaptation and long-term survival. Poster presented at the EMBO/FEMS Spetsai Summer School on the Molecular Basis of Bacterial Virulence and Survival within Infected Hosts and in the Environment, Spetses, Greece, 4-15 September 2006. Winner: Molecular Microbiology Best Poster Prize
  • Kana BD, Gordhan BG, Downing KJ, Sung N, Machowski EE, Matsoso LG, Shleeva M, Young M, Kaplan G, Kaprelyants AS, Mizrahi V. The role of resuscitation promoting-factor-like proteins in growth and resuscitation of Mycobacterium tuberculosis. Invited lecture presented at the International Scholars Meeting of the Howard Hughes Medical Institute, Janelia Farm Research Campus, VA, USA, 26-30 September, 2006
  • Savvi S, Mizrahi V, Dawes SS. Methylmalonyl CoA mutase (MCM) plays a nonredundant role in the metabolism of Mycobacterium tuberculosis. Talk presented at the Molecular and Cell Biology Group Symposium, University of the Witwatersrand, 5 October 2006.
  • Gordhan BG, Smith D, Kana BD, Bancroft G, Mizrahi, V. The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice. Talk presented at the Molecular and Cell Biology Group Symposium, University of the Witwatersrand, 5 October 2006.
  • Mizrahi, V. TB Research in the Post-Genomic Era. Invited lecture presented at Pandora’s Box: Implications of the Human Genome for Ordinary South Africans, Joint Faculty of Health Sciences and Health Graduates Association Symposium, University of the Witwatersrand, 25 November, 2006.
  • Gordhan BG, Boshoff HIM, Kana BD, Warner, Matsoso LG, Dawes SS, Downing KJ, Mizrahi, V. The application of genetic tools to investigate the molecular mechanisms of pathogenesis in Mycobacterium tuberculosis. Plenary lecture presented at the NICD Academic Day in Honour of the Official Opening of the NICD, National Institute for Communicable Diseases, Johannesburg, South Africa, 27-28 November, 2006.
  • van Helden PD. Antimicrobial Resistance in TuberculosisInternational Conference on Emerging Infectious Diseases. 19-22 March 2006. Atlanta, Georgia.
  • van Helden PD. Surrogate Markers to predict the outcome of anti-tuberculosis therapy. Third Annual Forum, EDCTP, 8-11 October 2006, Stockholm, Sweden.
  • Warren RM. TB Diagnosis: Past, Present and Future. Invited speaker TB day - 2 Military Hospital, March 2006.
  • Warren RM. PCR amplification. Invited speaker NHLS training on PCR, October 2006.
  • Warren RM. Role and Value of Molecular Investigation in TB Drug Resistance Surveys. Invited speaker at XDR-TB workshop – Johannesburg, September 2006.
  • Warren RM. Beijing in South Africa. TB in the 21st Century Consortium Meeting – Hanoi, Vietnam, February 2006.
  • Warren RM. Unlocking Epidemiological Secrets Through Comparative Genomics. Talk presented at the Bergen University, Norway, June 2006.
  • Gey van Pittius NC. Comparative Mycobacterial Genomics: uncovering the secrets of the genus Mycobacterium. Invited speaker, Department of Medical Microbiology, Vrije Universiteit Medical Centre, Amsterdam, Netherlands, April 2006.
  • Gey van Pittius NC. Environmental mycobacteria in a Western Cape population. Talk presented at the Cape Town TB Consortium Joint Symposium, Cape Town, March 2006.
  • Gey van Pittius NC. Non-tuberculous Mycobacteria (NTM) Isolated from a Community with a High Incidence of Tuberculosis: a Retrospective Study. 50th Academic Year day of the Faculty of Health Sciences of the University of Stellenbosch, Tygerberg, August 2006.
  • Gey van Pittius NC. Non-tuberculous Mycobacteria (NTM) Isolated from a Community with a High Incidence of Tuberculosis: a Retrospective Study”. Invited Oral Presentation, Royal Society/NRF Workshop on Cell wall lipids in Tuberculosis, Pretoria, South Africa, 29-30 June, 2006.
  • Gey van Pittius NC. Non-tuberculous Mycobacteria (NTM) Isolated from a Community with a High Incidence of Tuberculosis: a Retrospective Study”. Invited Oral Presentation at the XXth Conference of the South African Society of Biochemistry and Molecular Biology (SASBMB), Pietermaritzburg, South Africa, 2-5 July 2006
  • Victor TC, van Helden PD.TB Workshop with Department of Health and World Health Organisation, Johannesburg,  17-18 October 2006
  • Victor TC, van Helden PD. Workshop on Developing Demonstration Projects for Rapid Rifampicin Resistance Diagnostic Tools, Farm Inn Pretoria, 16 November 2006
  • Pheiffer C. Invited to the “Consortium to Respond Effectively against the Aids and Tuberculosis Epidemic” (CREATE) Investigator’s meeting held at Kwa Maritane Game Lodge in the North West Province, 18-19 September, 2006.
  • Gey van Pittius NC, van Helden PD. Invited talks, Livestock Health and Production Group Conference, Stellenbosch, August 2006
  • Uys PW, Warren R, van Helden PD, Murray M, Victor TC. The potential of rapid diagnosis for controlling drug-susceptible and drug-resistant TB in high prevalence communities. Poster presented at the TB and HIV Modelling Conference, Stellenbosch, November 2006.
  • Todorov SD, Wachsman MW, Wiid I, Brink M, Dicks LMT, Boza. A cereal-based beverage from Bulgaria is a source of probiotic lactic acid bacteria. Poster presented at the1st International symposium “Food, Veterinary and Medical Applications of Antimicrobial Peptides”. June 21st - 23rd 2006, ENITIAA, Nantes, France. Book of Abstracts, Section “Food and Medical Applications”, poster D-14, page 132.
  • Roberts T, Walzl G. Immune suppression of PBMC’S during active TB is restored by co-culture with cells obtained at treatment end. Poster presented at the1st joint meeting of European National Society of Immunology, Paris, France, 6-9 September 2006
  • Walzl G, Black GF, Stanley K, Loxton A, Chegou N, Golakai H, Nene N, Roberts T, Beyers N, Franken K, Friggen A, Ottenhoff T, Klein M and the Biomarkers4TB Consortium. Immunogenicity testing of new potential vaccine targets against Mycobacterium tuberculosis by whole blood assay in a population with high TB prevalence. TBV- TB vaccines for the World, 19-21 April 2006, Vienna, Austria.
  • Djoba Siawaya JF, Bapela NB, Veenstra H, Kidd M, Beyers N, van Helden P, Walzl G. Combined Immune Parameters and X-Ray Data in Early Prediction of Antituberculosis Therapy Response. Poster presented at the European Biomarkers Summit, Prague, Czech Republic, 26-27 September 2006
  • Hanekom M. Piecing Together The Evolutionary Puzzle Of The Mycobacterium Tuberculosis Beijing Strain Family. Poster presented at XXth Conference of the South African Society of Biochemistry and Molecular Biology (SASBMB), Pietermaritzburg, South Africa, July 2006.
  • Warren RM. Positive Association Between Site Of Disease And Mycobacterium Tuberculosis Strain In Children. Poster presented at the 37th Union World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (IUATLD), Paris, France, 31 October - 4 November 2006
  • Mahasha PW, Machowski EE, Warren RM, van Helden PD, Gey van Pittius NC. The trafficking of the Mycobacterium tuberculosis PE and PPE proteins. Poster presented at the27th African Health Sciences Conference, Durban, South Africa, 3-7 December 2006

Conferences / meetings hosted

  • Prof. Mizrahi served as Chair and Co-Organiser of the Workshop on Training in the TB Basic Sciences, Vineyard Hotel, Cape Town, 5 June 2006.
  • In March 2006, the SU node co-hosted the Cape Town TB Consortium Joint Symposium with the Institute for Infectious Diseases and Molecular Medicine (IIDMM) from UCT. This one day symposium included 4 sessions and covered topics related to the epidemiology of TB, Public Health, immunology and clinical aspects of tuberculosis research. Profs. Walzl and Warren chaired two of the sections and seven oral presentations were given by members of the CBTBR. Presentations included results from research on M. tuberculosis evolution, environmental mycobacteria in the Western Cape population, allelic variations and TB susceptibility and new approaches in TB drug evaluation.

Other Relevant Outputs (including honors and awards to staff)

  • Development of a spin-off company affiliated with the CBTBR – Task Applied Science, cc.
    Owner and full time employee, Dr. A. Diacon, pulmonologist. Task Applied Science currently employs 1 F/T and 2 P/T clinicians, 3 nursing sisters, 1 F/T and 1 P/T clerical staff, 1 driver, 4 medical technologists and pays 1 specialist medical consultants fees. For 2007, it is possible that the paid staff will increase by a further 6-7 persons and support for a clinical fellow is also planned.
  • Prof. Mizrahi was awarded the Gold Medal of the South African Society for Biochemistry and Molecular Biology (SASBMB), which she received at the biannual conference of the SASBMB in Pietermaritzburg in July 2006. The Gold Medal is awarded in recognition of lifetime achievements in research and capacity development in the fields of biochemistry and molecular biology in the field. Prof. Mizrahi is the first woman to receive this medal.
  • Prof. Mizrahi was awarded the DST Distinguished Woman Scientist Award for 2006 from the Department of Science and Technology. This award forms part of the annual DST Women in Science awards and is awarded to a senior woman scientist who has made significant contributions to the development of Science and Technology in South Africa.
  • Prof. Mizrahi won the Shoprite-Checkers/SABC2 2006 Woman of the Year award in the category of Science & Technology.
  • Prof. Warren was awarded the 2006 Stellenbosch University Rector’s Award for Excellence in Research
  • Prof. Mizrahi was appointed to the Scientific Advisory Committee of the EU-funded New Medicines for TB Program (NM4TB), which is based at the Institut Pasteur (Paris). She was also appointed to a three-year terms on the Committee on Genomics and Discovery of the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR).
  • Prof. Mizrahi was appointed to the Editorial Advisory Panel of the Biochemical Journal, the flagship journal of the Biochemical Society (UK), with an impact factor of 4.224. She is one of two panel members from South Africa
  • Dr. Gordhan’s Career Development Award from the MRC was renewed for a third year.
  • Dr. Kana received a Global Health Travel Award to attend the Keystone Conference on Tuberculosis, 20-24 March 2007, Vancouver, Canada.
  • Profs. van Helden and Walzl were invited to attend special panel meeting of GATB in December to discuss biomarkers
  • Dr. Gey van Pittius was appointed to a grants committee of the NRF
  • Dr. F. Sirgel was contracted by the Global Alliance for TB Drug Development to assist in assessing potential clinical trial sites for the evaluation of candidate anti-tuberculosis medication (May to December 2006).

Software Developed

  • A visual basic/MySQL-based results, patient management and sample management database system for the Gates GC-674 international collaborative project. The system stores and validates laboratory results and clinical report data, tracks the storage and usage of clinical samples and schedules follow-up visits.
  • A visual basic/MySQL-based database system for managing TB patients and their clinical samples and data at a remote clinic site in Lawaaikamp, George. The system uses fingerprint biometrics to identify patients' and track their clinic visits. Sputum samples are barcoded and tracked as they are processed from the clinic, through the NHLS, and then to the molecular lab at Tygerberg. Lab results are uploaded directly to the clinic via ADSL.
  • Ongoing development of a visual basic/MS access-based database used for recording and analysing the clinical and laboratory results of a number of TB projects.
  • Ongoing development of a PHP/MySQL-based DNA sequencer online job submission and management system used for tracking job status, accounting and statistical analysis of sequencer throughput.

Research


© CBTBR 2006 | Last updated: 17 August, 2015