Publications 2005

JOURNAL PUBLICATIONS

  1. Downing KJ, Mischenko VV, Shleeva MO, Young D, Young M, Kaprelyants AS, Apt AS, Mizrahi V. 2005. Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro. Infect. Immun. 73:3038-3043.

  1. Gey van Pittius NC, Sampson SL, Warren RM, van Helden PD. 2005. Genome variation in Mycobacterium tuberculosis: pathogens genomics. S. Afr. J. Sci. 100:465-470.

  2. Kaufmann SHE, Cole ST, Mizrahi V, Rubin E, Nathan, C. 2005. Mycobacterium tuberculosis and the host response. J. Exp. Med. 201:1693-1697.

  1. Loots DT, Wiid IJ, Page BJ, Mienie LJ, van Helden PD. 2005. Melatonin prevents the free radical and MADD metabolic profiles induced by antituberculosis drugs in an animal model. J Pineal Res. 38:100-6.

  2. Machowski EE, Dawes SS, Mizrahi V. 2005. TB tools to tell the tale: molecular genetic methods for mycobacterial research. Int. J. Biochem. Cell Biol. 37:54-68.

  1. Mardassi H, Namouchi N, Haltiti R, Zarrouk M, Mhenni B, Karboul A, Khabouchi N, Gey van Pittius NC, Streicher EM, Rauzier J, Gicquel B, Dellagi K. 2005. Tuberculosis due to Resistant Haarlem Strain, Tunisia. Emerging Infectious Disease.11(6):957-961.

  2. Mostowy S, Inwald J, Gordon S, Martin C, Warren RM, Kremer K, Cousins D, Behr MA. 2005. Revisiting the Evolution of Mycobacterium bovis. Journal of Bacteriology.  187:6386-6395.

  1. Matsoso LG, Kana BD, Crellin PK, Lea-Smith D, Peolis A, Powell D, Dawes SS, Rubin H, Coppel RL, Mizrahi, V. 2005. Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption. J. Bacteriol. 187:6300-6307.

  2. Pheiffer C, Betts JC, Flynn HR, Lukey PT, van Helden PD. 2005. Protein expression by a Beijing strain differs from that of another clinical isolate and Mycobacterium tuberculosis H37Rv. Microbiology. 151:1139-1150.

  1. Schaaf HS, Krook S, Hollemans DW, Warren RM, Donald PR, Hesseling AC. 2005. Recurrent culture-confirmed tuberculosis in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 24(8):685-91.

  2. Schaaf HS, Parkin DP, Seifart HI, Werely CJ, Hesseling PB, van Helden PD, Maritz JS, Donald PR. 2005. Isoniazid pharmacokinetics in children treated for respiratory tuberculosis. Arch. Dis. Child. 90:614-618.

  1. Shi L, Sohaskey CD, Kana BD, Dawes SS, North RJ, Mizrahi V, Gennaro ML. 2005. Changes in energy metabolism in Mycobacterium tuberculosis as revealed by transcriptional profiling during mouse lung infection and under in vitro conditions affecting aerobic respiration. Proc. Natl. Acad. Sci. USA. 102:15629-15634.

  2. Sholto-Douglas-Vernon C, Sandy J, Victor TC, Sim E, van Helden PD. 2005. Mutational and expression analysis of that and its response to isoniazid. Journal of Medical Microbiology. 54:1-9.

  1. Stopforth A, Tredoux A, Crouch A, van Helden P, Sandra P. 2005. A rapid method of diagnosing pulmonary tuberculosis using stir bar sorptive extraction-thermal desorption-gas chromatography-mass spectrometry. J Chromatogr A. 1071:135-9.

  2. van Rie A, Victor TC, Richardson M, Johnson R, van der Spuy GD, Murray EJ, Beyers N, Gey van Pittius NC, van Helden PD, Warren RM. 2005. Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns. Am J Respir Crit Care Med 1;172(5):636-42.

  1. Verver S, Warren RM, Beyers N, Richardson M, van der Spuy GD, Borgdorff MW, Enarson DA, Behr MA, van Helden PD. 2005. Rate of Reinfection Tuberculosis after Successful Treatment is Higher than Rate of New Tuberculosis. Am J Respir Crit Care Med. 171:1430-1435.

  2. Walzl G, Beyers N, van Helden P. 2005. TB: a partnership for the benefit of research and community. Trans R Soc Trop Med Hyg. 99 Suppl:515-519.

BOOKS

  • Chihota, VN, van Helden P, Victor TC, Warren RM. 2005 Molecular Epidemiology of Tuberculosis in South Africa:  Lessons learnt. In Molecular Epidemiology of tuberculosis, Eds. Academy of Science, Malaysia.

BOOK CHAPTERS

  • Mizrahi V, Buckstein M, Rubin H. 2005. Nucleic Acid Metabolism. In: Tuberculosis and the Tubercle Bacillus (Cole ST, Eisenach K, McMurray D, Jacobs WR Jr, eds), American Society for Microbiology Press, Washington DC, ch. 23, pp. 369-379.  ISBN: 1-55581-295-3.

  1. Brennan, MJ, Gey van Pittius NC, Espitia C. 2005. The PE and PPE multigene families of the Mycobacteria, In Tuberculosis and the Tubercle Bacillus (Cole ST, Eisenach K, McMurray D, Jacobs WR Jr, eds), American Society for Microbiology Press, Washington DC, ch. 33.  ISBN: 1-55581-295-3.

  2. Johnson R, Streicher EM, Louw GE, Warren RM, van Helden PD, Victor TC. 2005. Drug Resistance in Mycobacterium tuberculosis. In Mycobacterial Molecular Microbiology. Eds Horizon Scientific Press. (Chapter 5, Pages 169-197).

ABSTRACTS

  1. Fenhalls G, Stevens L, Sauk-Schubert C, Bezuidenhout J, Mustafa T, Litzky LA, Rubin H, Avarbock D, van Helden P, Lukey PT, Warren R, Walzl G.  Ziehl Neelsen and culture negative, yet metabolically active mycobacteria in sarcoid granulomas suggest that sarcoidosis is a persistent form of tuberculosis.  Blackwell Publishing Ltd, Immunology, 113, Supplement 1, 64.

CONFERENCES- INTERNATIONAL

  1. Bopape MC, Boshoff HI, Steel HC, Cockeran R, Matlola NM, Downing KJ, Mizrahi V, Anderson R. Phospholipases C and potassium transport knockout mutants of Mycobacterium tuberculosis to probe the molecular targets of antimicrobial action of clofazimine. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  1. Cynamon M, Sklaney M, Warren R, Victor T. Activities of isoniazid against isoniazid-resistant M. tuberculosis in a mouse model. The European Society of Mycobacteriology, Istanbul, Turkey. 2005.

  2. Dawes SS, Thomsen M, Freeman MF, Mizrahi V. The dual nature of Rv2228c, an Rnase H-CobC fusion? Poster presented at the Gordon Research Conference on vitamin B12 and corphins, Queens College, Oxford, UK, 8-13 September 2005.

  1. Gey van Pittius, NC, Botha, J, Madubanya, L, Van Helden, PD, and Warren, RM, Regulation of the Immunopathologically-important ESAT-6 Gene Cluster Operons. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  2. Gordhan BG, Smith DA, Bancroft GJ, Mizrahi V. Construction and phenotypic characterization of Mycobacterium tuberculosis mutants defective in genes induced in response to carbon starvation. Invited talk presented at the Conference on Functional Genomics for Novel Vaccine and Drug Design against Mycobacterial Infection, Department of Biotechnology, Indian Institute for Technology, Karagpur, India, 9-12 February 2005.

  1. Hayward D, Wiid I. Oxidative stress in Tuberculosis disease and treatment. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  2. Kana BD, Gordhan BG, Tsenova L, Sung N, Freeman S, Ellison E, Sacchettinin JC, Stoker NG, Mizrahi V. Characterization of a Y-family DNA polymerase from M. tuberculosis. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  1. Kana BD, Gordhan BG, Tsenova L, Sung N, Freeman S, Ellison E, Sacchettinin JC, Stoker NG, Mizrahi V. Characterization of a Y-family DNA polymerase from M. tuberculosis. Poster presented at the NITD Symposium on Tuberculosis, Bagamoyo, Tanzania, 16-20 October 2005

  2. Machowski EE, Warner DF, Barichievy S, Brackin R, Durbach SI, Kana BD, Springer B, Stoker NG and Mizrahi V. The development and application of reporter systems for assessing mutation rates in mycobacteria. Poster presented at the Joint Meeting of the International Union of Microbiological Sciences (IUMS 2005), San Fransisco, 23-28 July 2005. 

  1. Matsoso LG, Kana BD, Crellin PK, Lea-Smith DJ, Powell D, Dawes SS, Rubin H, Coppel RL, Mizrahi V. Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption. Poster presented at the Sixth International Conference on the Pathogenesis of Mycobacterial Infections, Stockholm, Sweden, 28-30 June 2005.

  2. Mizrahi V. Mutational mechanisms in mycobacteria. Invited lecture presented at the Joint Meeting of the International Union of Microbiological Sciences, IUMS 2005 Conference, San Fransisco, 23-28 July 2005.

  1. Mizrahi V. Post-Genomic Tuberculosis Research in South Africa - Lessons in Scientific Capacity Development. Invited lecture in honor of Ten years Post-Democracy, London School of Hygiene & Tropical Medicine, London, UK, 12 May 2005.

  2. Mizrahi, V. Participant at the Symposium on Science and Development to mark the 60th Anniversary of the CSIR, Pretoria, 28 September - 1 October, 2005.

  3. Mizrahi, V. The establishment and application of DNA microarray technology in the MMRU. Invited talk presented at the capar Microarray Technology Workshop, IIDMM, University of Cape Town, 25 October 2005.

  1. Mizrahi, V. Invited participant, Novartis Foundation Symposium on Innate Immunity in the Lung, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, 27-30 November 2005.

  2. Mizrahi, V. Pathogenesis mechanisms in M. tuberculosis. Invited lecture presented at the EMBO/ Novartis Foundation/ ICGEB/ DST Workshop on Innate Immunity in the Lung, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, 27-30 November 2005.

  1. Mizrahi, V. The application of molecular genetics in validating new TB drug targets. Plenary lecture presented at the IIDMM Grand Opening Conference: Understanding the Major Infectious Diseases of Africa, Cape Town, 22-24 March 2005.

  2. Mizrahi V. The role of error-prone DNA polymerases in damage tolerance and genetic adaptation in mycobacteria. Invited lecture, Dunn School of Pathology, Oxford University, Oxford, UK, 13 May 2005.

  1. Mizrahi, V. The challenges of applying new scientific tools to address the problem of TB in Africa. Plenary Address presented at the NITD Symposium on Tuberculosis, Bagamoyo, Tanzania, 16-20 October, 2005.

  2. Papavinasasundaram KG, Ko M, Chan BHY, Mizrahi V, Davis EO, Av-Gay Y. Roles of protein serine/ threonine kinases in M. tuberculosis physiology and virulence. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  1. Pheiffer C. Protein expression by a Beijing strain differs from that of another clinical  isolate and Mycobacterium tuberculosis H37Rv. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  2. Roberts T, Muller L and Walzl G. Phenotypic and functional characterization of immune suppressive T cells during Tuberculosis. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  1. Shi L, Kana BD, Sohaskey C, North RJ, Mizrahi V, Gennaro ML. The transitions to chronic infection in mouse lung and hypoxia-induced growth arrest in vitro are accompanied by a shift in the respiratory pathways of Mycobacterium tuberculosis. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  2. Van Helden PD. TB in the 21st Century. Changing TB Paradigms. Oslo, Norway 15-19 June 2005.

  1. Van Helden PD. Molecular Risk Factors for TB. Inflammatory Diseases of Barrier Organs. University Hospital Schleswig-Holstein, Germany. 3-4 June 2005.

  2. Van Helden PD. A search for surrogate markers for TB drug trials .NITD Symposium on Tuberculosis, Bagamoyo, Tanzania, October, 2005.

  1. Van Helden PD, Warren R, Michel A, Gey van Pittius NC, Hoal EG. Molecular characterization of animal and human mycobacterial isolates. Tropical animal Health and Production: Tuberculosis at the livestock / wildlife / human interface. Utrecht, Netherlands.October 2005.

  2. Van Helden PD. Forward to the Future, Tuberculosis Initiatives, GSk House, London, UK. 2005.

  1. Van Helden PD, Moller M, Babb C, Warren R, Walzl G, Uys P, Hoal E. TB Epidemiology and Human Genetics. Novartis Symposium: Innate Immunity to Pulmonary Infection, Cape Town 2005.

  2. Victor TC, Streicher EM, Warren RM, Jordaan AM, van der Spuy G, Kewley MC, Louw H, Bosman M, Murray M, van Helden PD. Clonal expansion of a highly drug resistant strain causes widespread MD-TB in South Africa. Poster presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

  1. Warner DF, Kana BD, Machoski EE, Brackin R, Gordhan BG, Dawes SS, Kaplan G, Stoker NG, Mizrahi V. The role of error-prone DNA polymerases in damage tolerance and genetic adaptation in mycobacteria. Lecture presented at the HHMI International Scholars Annual Meeting, Mérida, Mexico, 23-25 June, 2005

  2. Warner DF, Kana BD, Machowski EE, Brackin R, Gordhan BG, Dawes SS, Kaplan G, Barry CE III, Boshoff HIM, Stoker NG, Mizrahi V. The role of error-prone DNA polymerases in damage tolerance and genetic adaptation in mycobacteria. Invited lecture presented at the 2005 Keystone Symposium on Tuberculosis: Integrating Host and Pathogen Biology, Whistler, British Columbia, Canada, 2-7 April 2005.

CONFERENCES- NATIONAL

  1. Gey van Pittius, NC, Sampson, SL, van Helden, PD, and Warren, RM, Comparative Mycobacterial Genomics: uncovering the secrets of the genus Mycobacterium. Molecules-R-US, the 19th Meeting of the South African Society of Biochemistry and Molecular Biology, Stellenbosch, South Africa, January 2005.

  1. Mizrahi, V. Facilitator and co-organiser of the DST Workshop on National Priorities for Tuberculosis Research in South Africa, Cape Town, 9-10 November 2005.

  2. Mizrahi, V. Invited participant, Novartis Foundation Symposium on Innate Immunity in the Lung, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, 27-30 November 2005.

  1. Mizrahi, V. Participant at the Symposium on Science and Development to mark the 60th Anniversary of the CSIR, Pretoria, 28 September - 1 October, 2005.

  2. Mizrahi, V. Pathogenesis mechanisms in M. tuberculosis. Invited lecture presented at the EMBO/ Novartis Foundation/ ICGEB/ DST Workshop on Innate Immunity in the Lung, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, 27-30 November 2005.

  1. Mizrahi, V. The establishment and application of DNA microarray technology in the MMRU. Invited talk presented at the capar Microarray Technology Workshop, IIDMM, University of Cape Town, 25 October 2005.

  2. Pheiffer C, Betts JC, Flynn HR, Lukey PT, van Helden P. Differential protein expression by Mycobacterium tuberculosis strains. 19th South African Society of Biochemistry and Molecular Biology (SASBMB) conference. Stellenbosch, 2005.

  1. van Rie, A, Victor, T, Richardson, M, Johnson, R, van der Spuy, G, Murray, M, Beyers, N, Gey van Pittius, NC, van Helden, PD, Warren, RM, Mixed Mycobacterium tuberculosis infection: Changing drug-resistance patterns through antibiotic selection. (Poster). Molecules-R-US, the 19th Meeting of the South African Society of Biochemistry and Molecular Biology, Stellenbosch, South Africa, January 2005.

COMPLETED DOCTORAL THESES

  • Sholto-Douglas-Vernon, C. Characterization of the mycobacterial N-acetyltransferase. Stellenbosch Univ, 2005.

  1. Pheiffer, C.  Investigation of Mycobacterium tuberculosis protein expression and analysis of humoral immune responses of TB patients. Stellenbosch Univ, 2005.

  2. Warner, DF.  DNA metabolism in mycobacteria. Univ. Witwatersrand, 2005.

COMPLETED MASTERS DISSERTATIONS

  • Brackin, R. Expression and function of the mutator DNA polymerase-encoding umuC-like genes in mycobacteria. Graduated with Distinction, Univ. Witwatersrand, 2005.

  • Barichievy, S. Mutation rates in mycobacterial hosts with altered mutator DNA polymerase activity.  Graduated with Distinction, Univ. Witwatersrand, 2005.


Research


© CBTBR 2006 | Last updated: 17 August, 2015