Publications 2004

JOURNAL PUBLICATIONS

  • Boshoff, HIM., Barry, C.E. III and Mizrahi, V. 2004. Mutational dynamics in Mycobacterium tuberculosis: Implications for the evolution of drug resistance. S. Afr. J. Sci. 100:471-474.

  • Cowley, S, Ko, M, Pick, N, Chow, R, Downing, KJ, Gordhan, BG, Betts, JC, Mizrahi, V, Smith, DA, Stokes, RW, and Av-Gay, Y. 2004. The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamine/glutamate levels and is important for growth in vivo. Mol. Microbiol. 52:1691-1702.

  1. Downing, KJ, Betts, JC, Young, DI, Kelly, F, McAdam, R., Young, M, and Mizrahi, V. 2004. Global expression profiling of strains harbouring null mutations reveals that the five rpf-like genes of Mycobacterium tuberculosis show functional redundancy. Tuberculosis 84:167-179.

  2. Kana, BD, and Mizrahi, V. 2004. Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines. Tuberculosis 84:63-75.

  1. Springer, B, Sander, P, Sedlacek, L, Hardt, WD, Mizrahi, V, Schär and Böttger, EC. 2004. Lack of mismatch correction facilitates genome evolution in mycobacteria. Mol. Microbiol. 53:1601-1609.

  2. Warner, DF and Mizrahi, V. 2004. Mycobacterial genetics in target validation. Drug Discovery Today: Technologies 1:93-98.

  1. Apers L, Chihota V. Susceptibility of a series of routine sputum samples for antituberculosis chemotherapy in Gweru, Zimbabwe. SAMJ 2004; 94:282.

  2. Boshoff, HIM., Barry, CE III and Mizrahi, V. 2004. Mutational dynamics in Mycobacterium tuberculosis: Implications for the evolution of drug resistance. S. Afr. J. Sci. 100:471-474.

  3. Cowley, S, Ko, M, Pick, N, Chow, R, Downing, KJ, Gordhan, BG, Betts, JC, Mizrahi, V, Smith, DA, Stokes, RW, and Av-Gay, Y. 2004. The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamine/ glutamate levels and is important for growth in vivo. Mol. Microbiol. 52:1691-1702.

  1. Donald PR, Sirgel FA, Venter A, Parkin DP, Siefart HI, Wal BW, Werely C, van Helden PD, Maritz JS.  2004  The Influence of Human N-Acetyltransferase Genotype on the Early Bactericidal Activity of Isoniazid.  Clin Infect Dis  39 (10):1425-30

  2. Downing, KJ. Betts, JC, Young, DI, Kelly, F, McAdam, RA, Young, M, and Mizrahi, V. 2004. Global expression profiling of strains harbouring null mutations reveals that the five rpf-like genes of Mycobacterium tuberculosis show functional redundancy. Tuberculosis. 84:167-179.

  1. Eilers PH, Van Soolingen D, Thi Ngoc Lan N, Warren RM, Borgdorff MW. 2004. Transposition Rates of Mycobacterium tuberculosis IS6110 Restriction Fragment Length Polymorphism Patterns. J Clin Microbiol 42(6):2461-4.

  2. Fenhalls G. 2004. The use of Modern Molecular Techniques to Study Tuberculosis Immunology at the Site of the Disease. Current Allergy & Clinical Immunology. 17(4):167-172.

  1. Gey van Pittius NC, Sampson SL, Warren RM, van Helden PD.  Genome variation in Mycobacterium tuberculosis. 2004. South African Journal of Science 100 Pathogen Genomics, 465-470.

  2. Githui WA, Jordaan AM, Juma ES, Kinyanjui P, Karimi FG, Kimwomi J, Meme H, Mumbi P, Streicher EM, Warren R, van Helden PD, Victor TC. 2004. Identification of MDR-TB Beijing/W and other Mycobacterium tuberculosis genotypes in Nairobi, Kenya. Int J Tuberc Lung Dis. 8(3): 352-360.

  1. Hayward D, Wiid I, van Helden PD. 2004. Differential expression of mycothiol pathway genes: Are they affected by antituberculosis drugs? IUBMB Life. 56(3): 131-138.

  2. Hesseling AC, Schaaf HS, Victor T, Beyers N, Marais BJ, Cotton MF, Wiid I, Gie RP, van Helden P, Warren RM. 2004. Resistant M. bovis BCG disease: Implications for the management of BCG disease in HIV-infected children. Ped Infect Dis J. 23(5):476-9

  1. Hoal EG, Lewis LA, Jamieson S, Tanzer F, Rossouw M, Victor T, Hillerman R, Beyers N, Blackwell JM, van Helden PD. 2004. SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high incidence community in South Africa. Int J Tuberc. Lung Dis. 2004. 8(12):1464-71.

  2. Hoal EG, Möller M. 2004. Host Genetics and Predisposition to Tuberculosis. Current Allergy & Clinical Immunology. 17(4):160-165.

  1. Kana, B.D. and Mizrahi V. 2004 Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines. Tuberculosis. 84:63-75.

  2. Loots DT, Wiid IJ, Page BJ, Mienie LJ, van Helden PD. (2004)  Melatonin prevents the free radical and MADD metabolic profiles induced by antituberculosis drugs in an animal model. Journal of Pineal Research. 38(2):100-106.

  1. Mokrousov I, Bhanu NV, Suffys PN, Kadival GV, Yap S-F, Cho S-N, Jordaan AM, Narvskaya O, Singh UB, Gomes HM, Lee H, Kulkarni SP, Lim K-C, Khan BK, van Soolingen D, Victor TC, van Embden JDA. 200. Multicenter evaluation of reverse line blot assay for detection of drug resistance in Mycobacterium tuberculosis clinical isolates. J Microbiological Methods. 57(3):323-35.

  2. Nguyen D, Brassard P, Menzies D, Thibert L, Warren R, Mostowy S, Behr M. 2004. Genomic Characterization of an Endemic Mycobacterium tuberculosis Strain: Evolutionary and Epidemiologic Implications. J Clin Microbiol. 42(6):2573-80.

  1. Richardson M, van der Spuy G, Sampson SL, Beyers N, van Helden PD, Warren RM. 2004. Stability of polymorphic GC-rich repeat sequence-containing regions of Mycobacterium tuberculosis. J Clin. Microbiol. 42 (3): 1302-1304.

  2. Sampson SL, Richardson M, van Helden PD, Warren RM. 2004 IS6110-Mediated deletion polymorphism in isogenic strains of Mycobacterium tuberculosis. J Clin. Microbiol. 42 (2): 895-898.

  1. Schaaf HS, Parkin DP, Seifart HI, Werely C, Hesseling PB, van Helden PD, Maritz JS. Isoniazid Pharmacokinetics in children treated for respiratory tuberculosis. Arch. Dis. Child. 90: 614 - 618.

  2. Streicher EM, Warren RM, Kewley C, Simpson J, Rastogi N, Sola C, van der Spuy G, van Helden PD, Victor TC. 2004 Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa. J Clin. Microbiol. 12 (2): 891-894.

  1. Verver S, Warren RM, Munch Z, Richardson M, van der Spuy GD, Borgdorff MW, Behr MA, Beyers N, van Helden PD. 2004 Proportion of tuberculosis transmission that takes place in households in a high incidence area. The Lancet 363 (9404): 212-214.

  2. Verver S, Warren RM, Munch Z, Vynnycky E, van Helden PD, Richardson M, van der Spuy GD, Enarson DA, Borgdorff MW, Behr MA, Beyers N. 2004. Transmission of tuberculosis in a high incidence urban community in South Africa. In J Epidemiol 33(2): 351-357.

  1. Victor TC, de Haas PEW, Jordaan AM, van der Spuy G, Richardson M, van Soolingen D, van Helden PD, Warren R. 2004. Molecular characteristics and global spread of Mycobacterium tuberculosis with a Western Cape F11 genotype. J. Clin. Microbiol. 42 (2): 769-772.

  2. Walzl G, Hussell T, Nel H. 2004. Is the Hygiene Effect bad news for the Control of Infectious Diseases? Current Allergy & Clinical Immunology. 17(4):180-186.

  1. Walzl G. 2004. Addressing the Tuberculosis and Infectious Diseases Burden. Current Allergy & Clinical Immunology. 17(4):158. (Editorial).

  2. Warner, D.F. and Mizrahi, V. 2004. Mycobacterial genetics in target validation. Drug Discovery Today: Technologies 1:93-98.

  1. Warren RM, Victor TC, Streicher EM, Richardson M, Beyers N, Gey van Pittius NC, van Helden PD. 2004 Patients with active tuberculosis often have different strains in the same sputum specimen. Am J Respir Crit Care Med. 169: 610-614.

  2. Warren RM, Victor TC, Streicher EM, Richardson M, van der Spuy GD, Johnson R, Chihota VN, Locht C, Supply P, van Helden PD. 2004.  Clonal Expansion of a Globally Dissemnated Lineage of Mycobacterium tuberculosis with Low IS6110 Copy Numbers. J Clin. Microbiol, 42(12):5774-5782.

  3. Wiid I, Seaman T, Hoal EG, Benade AJS, Paul D van Helden. 2004).Total antioxidant levels are low during active TB and rise with anti-tuberculosis therapy. Research Communication. IUBMB Life 56(2): 101-106.

BOOK CHAPTERS

  • Van Helden PD, Warren RM, Uys P, van der Spuy GD, Victor TC. The molecular epidemiology of MDR-TB, In: Management of Multiple Drug-Resistant Infections. Publisher - Humana Press Inc. Totowa, New Jersey. 2004 (Edited by Stephen H. Gillespie). Part III: Mycobacteria, Chapter 13: 225-242.

  1. Brennan, M.J., Gey van Pittius, N.C., Espitia, C., The PE and PPE multigene families of the Mycobacteria, In “Tuberculosis”, 2nd edition, Publisher - ASM Press, Washinton, USA, 2004 (Edited by Stewart T. Cole, Kathleen D. Eisenach, David N. McMurray and William R. Jacobs, Jr.). Part X: Host Immune Responses and Antigenic Variation, Chapter 33.  ISBN: 1-55581-295-3.

ABSTRACTS

  • Beyers N, Michaelis I, Gie R, Schaaf S, Richardson M, Warren R, Fourie B, van Helden P. 2004. Transmission of tuberculosis (TB) to children in a high incidence area.  Int. J. Tuberc. Lung Dis. 5(11):S185.

REGISTERED PATENTS

  • High Copy-number Plasmid Replicon. Patent holder: SA MRC/Univeristy of Stellenbosch. Inventors: Bourne, W, van Helden PD, Warren RM, Jansen Y. Feb 2004.

CONFERENCES - INTERNATIONAL

  • Bhakta S, Sholto-Douglas Vernon C, Samson S, Mo MSN, Upton A, van Helden P, Victor T, Sim E. Localisation and expression in Mycobacteria of Arylamine N-acetylatransferase, a novel target for anti-tuberclar drugs. TB Conference in New Delhi,  2004

  1. Mizrahi V. DNA metabolism in mycobacteria. Plenary lecture presented at the ICGEB Tuberculosis Symposium, International Center for Genetic Engineering and Biotechnology, New Delhi, India, 15-17th November 2004.

  2. Mizrahi V. Mutational dynamics in Mycobacterium tuberculosis: implications for the evolution of drug resistance and strain variation. Invited lecture presented at the Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, 19th May 2004.

  1. Mizrahi V. The development and application of genetic tools for investigating molecular mechanisms in Mycobacterium tuberculosis. Lecture presented at the 3rd Wellcome Trust/ EMBO Workshop: AIDS and TB, The Way Ahead. University of Cape Town, 29 November - 6 December 2004.

  2. Ramoutar, R “The Induction of Cellular Immune Responses by Mycobacterial Antigens in a Family-based Study in South Africa” to be presented July in Montreal at the FOCIS/ICI 2004 Immunology Congress (Poster).

  1. Streicher EM, Warren RM, Jordaan AM, Johnson R, Engelke E, Kewley C, Bosman M, van der Spuy G, van Helden PD, Victor TC. Charisteristics of Micro-epidemics of Drug Resistant Mycobacterium Tuberculosis Isolates from Rural Districts of the Western Cape Province in South Africa. American Society for Microbiology, New Orleans, Louisiana, May 2004

  2. Victor T, Streicher L, Jordaan A, van Helden P, Johnson R, Warren R. Drug resistant tuberculosis in the Western Cape. Imperial College, London. May 2004.

  1. Walzl, G. American Society for Tropical Medicine and Hygiene Society Conference in Miami 7-11 November 2004.

  2. Walzl, G.  British Society of Immunology Annual Congress, Harrogate, UK, 7-10 Dec 2004.

  1. Warner DF, Machowski EE, Kana BD, Barichievy S, Brackin R, Stoker NG, Sacchettini JC, Boshoff HIM, Dawes SS, Mizrahi V. The individual and collective roles of mutator DNA polymerases in genetic adaptation and long-term survival of mycobacteria. Poster presented at the Annual International Scholars meeting of the Howard Hughes Medical Institute, Tallin, Estonia, 23-28th June 2004.

  2. Warner DF, Machowski EE, Kana BD, Barichievy S, Brackin R, Stoker NG, Boshoff HIM, Dawes SS, Mizrahi V. Y-family polymerases in mycobacteria: roles in genetic adaptation and long-term survival. Poster presented at the ASM Conference on DNA Repair and Mutagenesis: From Molecular Structure to Biological Consequences, Southampton,
CONFERENCES NATIONAL (SOUTH AFRICAN)
  1. Hoal van Helden EG.   Is Tuberculosis in the Genes? 18th Congress of the South African Genetics Society, Stellenbosch. 4 - 7 April 2004, Stellenbosch. Western Cape province.

  1. Chihota V, Apers L, Mungofa S, Kasongo W, Nyoni I, Ndabambi S, Streicher EM, Victor T, van Helden P, Warren R.  Predominance of the SAF1 Genotype of M. Tuberculosis in Regions of Southern Africa. 48th Academic Yearday of the Faculty of Health Sciences of the University of Stellenbosch, Tygerberg, August 2004.

  2. Dabbs, E.R. and Mowa MB. Cloning and characterization of a gene responsible for acrylamide bioremediation. MCBG Annual Symposium, University of the Witwatersrand, Johannesburg, 6th October 2004.

  1. Streicher EM, Warren RM, Jordaan AM, Johnson R, Engelke E, Kewley C, Simpson J, van der Spuy G, Sola C, Rastogi N, van Helden PD, Victor TC. Micro-epidemics of drug resistant Mycobacterium tuberculosis. 18th Congress of the South African Genetics Society, 4 - 7 April 2004, Stellenbosch. Western Cape province.

  2. Gey van Pittius NC, Sampson SL, Lee H, Kim Y, van Helden, PD, and Warren RM  The evolution of the Mycobacterium tuberculosis PE and PPE multigene families. 48th Academic Yearday of the Faculty of Health Sciences of the University of Stellenbosch, Tygerberg, August 2004.

  1. Gordhan BG, Smith DA, Mizrahi V. Construction and phenotypic characterization of Mycobacterium tuberculosis mutants defective in genes induced in response to carbon starvation. Poster presented at the Research Day, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 4th August 2004.

  2. Johnson R, Warren R, van Helden P, Streicher E, Victor T.  Molecular Characterization of the Drug Resistant Beijing / W-like Strain. 48th Academic Yearday of the Faculty of Health Sciences of the University of Stellenbosch, Tygerberg, August 2004.

  1. M Rossouw, H Nel, C Babb, P van Helden, E Hoal.  The Importance of Interferon-Gamma. 18th Congress of the South African Genetics Society, 4 - 7 April 2004, Stellenbosch. Western Cape province: Micro-epidemics of drug resistant Mycobacterium tuberculosis.

  2. Mizrahi V. Building a Center of Excellence in Biomedical Research in South Africa - Opportunities and Challenges. Special Address presented at the Research Day, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 4th August 2004.

  1. Mizrahi V. Taming the White Plague: Post-genomic tools for identifying and validating targets for new TB drugs and vaccines. Inaugural Distinguished Science Alumni Lecture, University of Cape Town, 27th October 2004.

  2. Johnson R, Jordaan AM, Pretorius L, Engelke E, Kewley C, Bosman M, van Helden PD, Warren R, and Victor TC.  Molecular Phenotyping: An Adjunct to Management of Drug Resistant - tuberculosis. 18th Congress of the South African Genetics Society, 4 - 7 April 2004, Stellenbosch. 

  1. Streicher EM, Warren RM, Jordaan AM, van der Spuy GD, Kewley Bosman M, Sola C, Rastogi N, van Helden PD, Victor TC.  Clonal Expansion of a highly drug resistant strain causes widespread MDR-TB in South Africa.  48th Academic Yearday of the Faculty of Health Sciences of the University of Stellenbosch, Tygerberg, August 2004.

  2. Roos T, van Helden P, Hoal E.  Association Between Surfactant Protein D Polymorphisms and Serum Concentration. (Poster).18th Congress of the South African Genetics Society, Stellenbosch, 4-7 April 2004. 

  3. Victor T.  Control of drug resistant Tuberculosis: a molecular approach.2004 4th Academic Day, SMLTSA, Tygerberg Branch, May 2004.

  1. Victor T. Micro-epidemics of drug resistant TB in local communities.National Tuberculosis control program task force meeting: February 2004.

  2. Van Helden PD. Genotype and Phenotype: From Bacteria to Humans. 18th Congress of the South African Genetics Society, Stellenbosch, 4-7 April 2004. 

  1. Van Rie A, Victor T, Richardson M, Johanson R, van der Spuy G, Murray E, Beyers N, van Helden P, Warren R.  Alternating Drug Resistance patterns during Tuberculosis treatment:  Acquisition, Reinfection or Multiple infection?   48th Academic Yearday of the Faculty of Health Sciences of the University of Stellenbosch, Tygerberg, August 2004.

  2. Warren R, van Rie A, Victor T, Gey van Pittius N, Richardson M, Streicher E, Johnson R, van der Spuy G, Beyers N, van Helden P.  Population structure of Mycobacterium Tuberculosis in the human host. Path Splash, FSASP 44th Annual Conference with SASCC, 4 - 7 July 2004, Stellenbosch. 

COMPLETED DOCTORAL THESES

  1. Adams JFA. Immune responses in a community with a high incidence of tuberculosis. Stellenbosch Univ. March 2004.

COMPLETED MASTERS DISSERTATIONS

  • Barnard, D. Risk Factors associated with the development of INH resistance in Beijing/W isolates.  Nucleotide sequence variation and expression levels of critical genes associated with cancer of the upper gastro-intestinal tract. Stellenbosch Univ. 2004.

  • Lundwall-Roos TA.  An Investigation into the Role of Collectins in Tuberculosis Infection. Stellenbosch Univ, 2004.


Research


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