Networks and linkages
The three nodes of the CBTBR are involved in wide collaborative networks that involve TB researchers and research institutions in a large number of countries. Maintaining existing collaborative networks and developing new linkages is of critical importance to the CBTBR. For this reason, members continued to devote significant time and effort to networking.

International (46)

Dr. Neeraj Dhar

Faculte Des Sciences De La Vie, Global Health Institute Ecole Polytechnique Federale De Lausanne

Collaboration on the study of peptidoglycan remodelling and cell division in mycobacteria and on the use of microfluidics to analyse the impact of drug treatment or target depletion on M. tuberculosis.

Prof. Katarina Mikusova

Comenius University, Bratislava

MM4TB collaboration on cell wall biosynthesis

Prof. Česlovas Venclovas

Institute of Biotechnology, Vilnius, Lithuania

Ongoing collaboration on computational biology of M. tuberculosis proteins

Dr. Tom Ioerger,  Prof. Jim Sacchettini

Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA

Ongoing collaboration on whole-genome sequence analysis of strains of M. tuberculosis

Prof. Sir Tom Blundell, Prof. Chris Abell

Cambridge University, UK

Collaborating members of the HIT-TB and MM4TB Consortia

Prof. Stewart Cole and other MM4TB collaborators

EPFL, Lausanne, Switzerland

MM4TB Consortium

Prof. Menico Rizzi

University of Piemonte Orientale, Novara, Italy

Onngoing collaboration on TB drug discovery (MM4TB)

Prof. Hannu Mykyllallio

INSERM, France

Ongoingcollaboration on targeting ThyX for TB drug discovery

Prof. Rolf Müller

HIPS Helmholtz Institute for Infection Research, Saarland, Germany

Ongoing collaboration on the identification of natural products of myxobacterial origin with antimycobacterial activity

Prof. David Russell

Cornell University, USA

Ongoing  collaboration on drug permeation

Prof. Dirk Schnappinger, Dr. Sabine Ehrt

Weill Cornell Medical College, Cornell University, USA

Ongoing collaboration on in vivo validation of drug targets

Prof. Kyu Rhee

Weill Cornell Medical College, Cornell University

Ongoing collaboration on metabolomics analysis of conditional mutants of M. tuberculosis

Dr. Roger Woodgate


Onoing collaboration on replisone dynamics in mycobacteria. Co-investigator with A/prof. Digby Waner on new five-year UO1 grant from the NIH

Dr. Ian Orme

Colorado State University

Collaboration on characterization of mutant strains of M. tuberculosis in the guinea pig model of TB infection.

Dr. Helmi Mardassi

Institut Pasteur de Tunis, Tunisia

Characterisation of LAM evolutionary history (2007-present).

Dr. Wilbert Bitter

Vrije Universiteit, Amsterdam, Netherlands

The trafficking of the M. tuberculosis PE and PPE proteins (2006 – present). ESX secretion in Beijing genotype strains

Dr. Philip Supply,

Institut Pasteur Lille

Evaluation of hypervariable VNTR regions for the discrimination of Beijing genotype strains

Dr Bob Horseburgh

Boston University

Deep sequencing for fluoroquinolone resistance

Prof. Sebastian Gagneux

Swiss TPH, Basel, Switzerland

Collaboration on genome sequencing of clinical strains of M. tuberculosis

Profs. Larry Wangh and Prof. Barry Kreiswirth

Brandis University, HPRI,

Evaluation of LATE PCR for the detection of resistance to first and second-line anti-TB drugs.

Dr. Clifton E. Barry III, Dr. Helena Boshoff

Tuberculosis Research Section, Laboratory of Host Defenses, National Institute of Allergy & Infectious Diseases, NIH, MD

Ongoing collaboration on the HIT-TB project

TB treatment response project with SUNIRG (G Walzl)

Prof Blanca Restrepo

University of Texas

ALERT: Altered endocrine axis during type 2 diabetes and risk for tuberculosis

Dr Mickey Urdea

Catalysis Foundation

Catalysis/Biomarker: Mycobacterium tuberculosis Biomarkers for Diagnosis and Cure

Prof John Belisle

Colorado State University


Stefan Kaufmann

Max Planck IIB


Hazel Dockrell



Prof Tom Ottenhoff

Leiden University

Ongoing collaboration of biomarkers for TB diagnostics

Prof Eric Bottger

University of Zurich

Development and evaluation of novel genetic based diagnostics for drug resistance.

Prof. Timothy Sterling

Vanderbilt University Tuberculosis Center, Nashville, USA

Fluoroquinolone resistance

Prof Megan Murray

Florida University Harvard / Broad institute

Various project including the evolution of XDR-TB strains; other mechanisms of drug resistance (in addition to genomic mutations); mechanisms of resistance to 2nd line drugs; strain fitness; certain strain families may have both increased fitness and increased potential for acquiring drug resistance.

Dr. Karen Jacobson

Harvard University, USA

  1. GIS of drug resistant TB in the Western Cape
  2. Health systems reserach

Prof. Harald Wiker, Dr Gustavo de Souza

Bergen University and Oslo University, Norway

Ongoing collaboration on M. tuberculosis proteomics.

Dr. Hernandez Pando Rogelio

National University of Mexico

Test different drug resistant strains (MDR / XDR) in a mouse model for strain fitness/virulence.

Prof. Ruth McNerey


Whole genome sequencing of drug resistant M. tuberculosis strains

Prof. Anab Pain


Whole Genome Sequencing of Mycobacterial Species

Prof. Erwin Schurr

McGill University, Montreal, Canada

Genetic epidemiology. Poster outputs; 4 papers published 2009-2010, one paper in 2013, one in 2014.

Prof. Laurent Abel & Alexandre Alcais

INSERM / Université Paris 5, France

Analysis of genetic epidemiology. Poster outputs; 4 papers published 2009-2010, one paper in 2013, one in 2014.

Dr. Alkes Price

Harvard School of Public Health, Boston, USA

Computational assistance with analysis of admixture mapping. Paper published in 2013

Dr. Brenna Henn

Stony Brook University, New York, USA

Population Ancestry genetic determinations. Paper published in 2013 and 2014

Prof. Stefan Schreiber, Dr. Almut Nebel, Dr. Andre Franke

Christian-Albrechts University, Kiel, Germany

Investigation of candidate genes in TB. Resulted in 4 publications 2007 - 2009. Manuscript in preparation

Dr. Ad Koets

Utrecht University

Host genetics of BTB (WOTRO Integrated program proposal) (2007 - present). Two papers published 2013

Prof. Mary Carrington, Dr. Maureen Martin, Dr. Xiaojiang Gao

Frederick National Laboratory for Cancer Research, Maryland

Investigation of KIRs as TB candidate genes. Paper published 2014

Dr Chris Gignoux

Stanford University, USA

Population Ancestry genetic determinations. Paper published in 2014

Dr John Metcalfe


Deep sequenceing to identify heteroresistance

Prof. Annelies van Rie,


Evaluation of the Xpert MTB/RIF test.

Prof Nalin Rastogi

Pasteur Institute

Spoligotyping TB in Africa

National (37)

Dr. Musa Mhlanga

Council for Scientific and Industrial Research

Ongoing collaboration to develop methods for super-resolution microscopy in mycobacteria

Prof. Kelly Chibale and other members of H3D

H3D Drug Discovery & Development Centre, UCT

Ongoing collaboration on SATRII, HI-TB and H3-D TB drug discovery projects

Prof. Robert Wilkinson


Collaboration on sequence analysis of clinical strains of M. tuberculosis

Prof. Robin Wood


Ongoing collaboration on TB transmission

Prof. Adrie Steyn


Ongoing collaboration on SATRII TB drug discovery project

Prof. Tom Scriba


Ongoing collaboration on TB transmission

Dr. Jeremy Wodward & Prof. Trevor Sewell


Ongoing collaboration on structural biology and imaging of M. tuberculosis

Dr. Lubbe Wiesner


Ongoing collaboration on pre-clinical pharmacology

Dr. Helen Cox


Evolution of drug resistance in HIV positive and negative individuals

Prof. Keertan Dheda


Molecular epidemiology of XDR-TB
Whole genome sequencing of XDR-TB

Collaboration in diagnostic/biomarker project

Prof. Alan Christoffels


Bioinformatic analysis of whole genome sequence data.Wet-lab testing of computationally identified inhibitors

Dr. Nazir Ismail


Drug resistant TB in South Africa

Dr. Danie Theron

Eben donges hospital, Worcester

New project on DOTS program on farms.

Prof. Lesley Scott, Prof. Wendy Stevens

University of the Witwatersrand

Ongoing collaboration on the rollout of the GeneXpert diagnostic test and establishment of an external quality assurance system.

Prof. Jonathan Blackburn


Collaboration on lipidomic and proteomic analyses of M. tuberculosis strains

Prof. Nicola Mulder


Collaboration on bioinformatic analysis of mycobacterial genomes and transcriptomes

Dr. Violet Chihota

Aurum Health

M. tuberculosis strain population structure in Africa.

Prof. Du Toit Loots

North West University, Potchefstroom

Mouse Macrophagemetabolome.

Prof. Colleen Wright

NHLS Port Elizabeth

The diagnostic utility of FNAB

Drs. Peter Buss & Markus Hofmeyr

SA National Parks

Development of a gene transcription assay for lions; ongoing project 

Dr. Anita Michel, Jacques Godfroid, Koos Coetzer, Nick Kriek

Onderstepoort Veterinary Institute

Non-tuberculous mycobacteria in wildlife (WOTRO Integrated program proposal) (2007 - present).

Dr Chris van der Westhuyzen

CSIR Biosciences,Pretoria

Screen antituberculosis lead compounds

Dr. Richard Haynes

North West University, Potchefstroom

Study novel artemisinins for antimycobacterial activity

Dr Gert Kruger

Chemistry, UKZN, Durban

Screen antituberculosis lead compounds

Mrs Tania Dolby

NHLS , Green point

Collaborator provides routine samples.

Dr. Anneke Hesseling


New collaboration to investigate genotype-immunological phenotype correlations in children.
Collaboration of developing a stool TB diagnostic

Prof. Muazzam Jacobs


New collaboration to assess the impact of steroid hormones on protective immunity to M. tuberculosis in a mouse animal model.

Dr. Elisabetta Walters

Department of Pediatrics and Child Health, Stellenbosch University

Improved detection of M. Tb by Xpert MTB/RIF in gastric aspirates and stool samples collected from children with suspected pulmonary TB.

Dr Monika Esser,

NHLS Immunology Unit, Tygerberg Hospital

Identification of gene mutations that cause Primary Immunodeficiency Disorders.

Prof Rafique Moosa

Dept. Medicine, SU

Investigating chromosome 22 genetic polymorphisms as risk factors for HIVAN in South African adults: a pilot case-control study

Prof Ronald van Toorn
Dr Regan Solomons

Dept of Medicine, SU

Investigating susceptibility to tuberculous meningitis

Kogie Naido


Systems immunology project

Gavin Churchyard

Aurum Institute

Systems immunology project

Prof Mark Hatherill
Prof Tom Scriba

SA Tuberculosis Vaccine Initiative (SATVI), UCT

CORTIS: The Correlate of Risk Targeted Intervention Study

Prof Mark Cotton




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© CBTBR 2006 | Last updated: 23 June, 2016