| NAME |
INSTITUTION |
NATURE/ PURPOSE, OUTPUTS AND FUTURE DIRECTION OF COLLABORATION |
Prof. John D. McKinney |
École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
Collaboration on the mechanisms of propionate catabolism, co-author on a manuscript published in 2008 and joint awardee (with Prof. Mizrahi) on a three-year grant from Swiss/ SA Joint Research Programme. Dr. Warner visited Prof. McKinney’s lab in July to discuss the collaborative research project. |
Dr. Clifton E. Barry III and Dr. Helena Boshoff |
Tuberculosis Research Section, Laboratory of Host Defenses, National Institute of Allergy & Infectious Diseases, NIH, Rockville, MD |
Collaborating members of the “IM TB” Consortium funded through SBRI. Hosted Dr. Garth Abrahams during his 4-month working visit to the NIAID in 2009. |
Prof. Gilla Kaplan |
Public Health Research Institute, International Center for Public Health, Newark, NJ |
Ongoing collaboration in the area of in vivo phenotyping of mutant strains of M. tuberculosis. Profs Kaplan & Mizrahi Jointly run the TB Basic Sciences component of the CU-SA Fogarty AITRP. Visited the Wits node in October 2009 |
Prof. Česlovas Venclovas |
Institute of Biotechnology, Vilnius, Lithuania |
New collaboration on the structure and function of a novel mutagenic complex in mycobacteria. Spent a week in the Wits node in March 2009 to further the collaboration with Dr. Warner and Ms. Ndwandwe |
Prof. Heini Dirr |
University of the Witwatersrand |
New collaboration on the expression and structure determination of members of a novel mutagenic complex in mycobacteria |
Dr. Deborah Hung |
Broad Institute of Harvard and MIT, Boston, USA |
Collaborating member of the “IM TB” Consortium funded through the SBRI. Also collaborating on the characterization of Rpf-deficient mutants of M. tuberculosis |
Prof. Eric Rubin |
Microbiology and Immunology, Harvard Medical School, USA |
Collaborating member of the “IM TB” Consortium funded through SBRI. Visited the MRU in November 2009. Will co-host Ms. Ndwandwe during her Fogarty training fellowship in 2010 |
Prof. David Sherman |
Seattle Biomedical Research Institute, USA |
PI of the “IM TB” Consortium funded by the Bill & Melinda Gates Foundation |
Prof. James Sacchettini and Dr. Tom Ioerger |
Biochemistry and Biophysics, Texas A&M University, College Station, TX |
Collaborating members of the “IM TB” Consortium funded through the SBRI. Also collaborating on whole-genome sequence analysis of strains of M. tuberculosis. |
Prof. Sir Tom Blundell and Prof. Chris Abell |
Cambridge University, UK |
Collaborating members of the “IM TB” Consortium funded through the SBRI |
Prof. Jean Content |
Institut Pasteur Bruxelles, Brussels, Belgium |
Collaboration on genome duplication in M. smegmatis resulted in co-authored publication in 2006 |
Dr. Chris Sassetti |
University of Massachusetts, USA |
Collaborating member of the “IM TB” Consortium funded through the SBRI |
Prof. Tanya Parish |
Barts and the London, UK & Infectious Diseases Research Institute (IDRI), Seattle, USA |
Collaborating member of the “IM TB” Consortium funded through the SBRI |
Prof. Stewart Cole |
EPFL, Lausanne, Switzerland |
PI of the More Medicines for Tuberculosis (MM4TB) Consortium, which has applied for funding under the EU FP7 framework |
Prof. Vickery Arcus |
AgResearch, University of Waikato, New Zealand |
Collaboration on the role of VapBC toxin-antitoxin modules in the physiology of M. tuberculosis |
Prof. Gregory Cook |
University of Otago, Dunedin, New Zealand |
Collaboration on the role of VapBC toxin-antitoxin modules in the physiology of M. tuberculosis |
Prof. Petros Karakousis |
Johns Hopkins University, Baltimore |
New collaboration on nucleotide pool determination in mycobacteria. Will host Dr. Cliff Magwira in 2010 for short-term training fellowship |
Dr. S. Sampson |
Imperial College, UK |
The evolution and function of the PE and PPE gene families (2001-present) & the ESAT-6 secretion system interactome (2007- present). |
Dr. H. Mardassi, Mr. A. Karboul and Mr. A. Namouchi |
Institut Pasteur, Tunisia |
Characterization of M. tuberculosis lineages through the PE/PPE gene family (2002 - present) |
Dr. W. Bitter and Mr A. Abdallah |
Vrije Universiteit, Amsterdam, Netherlands |
The trafficking of the M. tuberculosis PE and PPE proteins (2006 – present). |
Dr. John Ho |
Cornell University, New York, USA |
Characterization of M. tuberculosis lineages through the PE/PPE gene family (2007 - present). |
Prof. J. Ho, Dr. A. Gibson and Prof. R. Huard |
Cornell University, New York, USA |
The dissemination of the major RDRio sub-lineage of the LAM M. tuberculosis spoligotype family in Luso-American countries, Portugal and Africa |
Dr. H. Mardassi |
Institut Pasteur de Tunis, Tunisia |
Characterisation of LAM evolutionary history (2007-present). |
Prof. A. Steyn |
University of Alabama, Birmingham, USA |
The ESAT-6 secretion system interactome (2007- present). |
Prof. VPMG Rutten, Dr. I van Rhijn, Dr. AP Koets |
Utrecht University |
Non-tuberculous mycobacteria in wildlife (WOTRO Integrated program proposal) (2007). |
Dr. R Anthony |
KIT The Netherlands |
MLPA assay for the detection of ofloxacin resistance |
Prof D van Soolingen |
RIVM The Netherlands |
Evolution of the Beijing genotype Lineage |
Dr. Kristin Kremer |
RIVM The Netherlands |
Whole genome sequencing of Beijing genotype strains |
Dr. V Dartois |
Novatis Singapore |
MassArray detection of mutations conferring drug resistance |
Prof. E Bottger |
University of Zurich |
Development and evaluation of novel genetic based diagnostics for drug resistance. |
Prof. E Nardell |
AIR facility, Witbank |
Transmissibility of drug resistant TB |
Prof. Sturm |
UKZN and LifeLab |
Whole genome sequencing and development of a genetic based diagnostic for second-line drug resistance |
Prof. Erwin Schurr |
McGill University, Montreal, Canada |
Genetic epidemiology. Poster outputs; 4 papers published 2009-2010. |
Prof Laurent Abel & Alexandre Alcais |
INSERM / Université Paris 5, France |
Analysis of genetic epidemiology. Poster outputs; 4 papers published 2009-2010. |
Dr. Iris Grossman |
GlaxoSmithKline, NC, USA |
Genetic susceptibility to TB. |
Dr. Alkes Price |
Harvard School of Public Health, Boston, USA |
New collaboration. Analysis of admixture mapping. |
Dr. Ingileif Jonsdottir |
decode, Iceland |
Genetic susceptibility to TB. |
Dr. Lluis Quintana-Murci |
Institut Pasteur, Paris,
France |
Genetic susceptibility to TB and population structure. Paper expected 2010. |
Prof. Stefan Schreiber and Dr. Almut Nebel |
Christian Albrechts University, Kiel, Germany |
Investigation of candidate genes in TB. Resulted in 2 co-authored publications in 2007, and 2 co-authored publications in 2009 |
Prof .Megan Murray |
Harvard / Broad institute |
Various project including the evolution of XDR-TB strains; other mechanisms of drug resistance (in addition to genomic mutations); mechanisms of resistance to 2nd line drugs; strain fitness; certain strain families may have both increased fitness and increased potential for acquiring drug resistance. All of these projects involve whole-genome sequencing, proteomics, and microarray. Prof. Murray is directly involved in project planning, paper writing, funding proposals (NIH and Wellcome trust). |
Dr. Judit Nagy |
Imperial College London |
Proteomics of large clusters (more transmitted) vs. small clusters (less transmitted) in the same strain family after other criteria to select isolates have been taken into consideration. The aim is to identify proteins that are differentially expressed in the same strain family which may give them an advantage to transmit better. |
Prof. Harald Wiker |
Bergen University, Norway |
Ongoing collaboration on the M. tuberculosis phosphorylome.
New collaboration on the detection of drug resistance by single run multi-locus sequencing.
New collaboration on the M. tuberculosis secretome. |
Dr. Hernandez Pando Rogelio |
National University of Mexico |
Test different drug resistant strains (MDR / XDR) in a mouse model for strain fitness/virulence. The isolates are the same as described above and will compliment the data obtained by molecular investigations. |
Dr. Cheryl McDermott |
MSF |
New collaboration on drug resistance in Khayelitsha, Western Cape. |
Prof. Tom Alber |
Berkeley |
New collaboration on the M. tuberculosis lipidome. |
Prof. Brigitte Gicquel |
Pasteur Institute |
New collaboration on mutation in M. tuberculosis DNA repair genes. |
Prof. Kathy Eisenach |
Arkansas, USA |
Mechanisms of strain fitness in an in vitro THP-1 cell line model. Project is in planning phase. |
Prof. Stefan Kaufmann |
Max Planck Institute for Infection Biology, Berlin, Germany |
Collaborators on BMGF-funded project. |
Prof. Henry Boom |
Cleveland, Ohio, US |
Collaborators on BMGF-funded project. |
Prof. Hazel Dockrell |
London School for Hygiene and Tropical Medicine, London, UK |
Collaborators on BMGF-funded project, Co-applicants on grant application to BMGF. |
Dr. Mark Doherty |
Statens Serum Institute, Kopenhagen, Denmark |
Collaborator on BMGF-funded project, collaborators on NIH-sponsored study |
Dr. Martin Ota |
MRC, The Gambia |
Collaborators on BMGF-funded project. |
Prof. Harriet Mayanja |
Makarere University, Uganda |
Collaborators on BMGF-funded project. |
Prof. Ronnie Anderson & Dr. Caroline Cholo |
MRC/ UP Unit on Inflammation & Immunity, University of Pretoria |
Collaboration on the role of potassium transport in mode of action of anti-tubercular action of riminophenazines. |
Prof N. Beyers, Dr A. Hesseling, Dr S. Tonkin, Prof B. Marais |
SU |
Non-tuberculous Mycobacteria (NTM) - Prevalence and Clinical relevance in HIV-infected and HIV-uninfected children (2006 - present). |
Prof. N. Beyers |
DTTC, SU |
Ongoing collaboration of the molecular epidemiology of M. tuberculosis in the W. Cape. |
Dr. A. Michel, J. Godfroid, K. Coetzer & N. Kriek |
Onderstepoort Veterinary Institute |
Non-tuberculous mycobacteria in wildlife (WOTRO Integrated program proposal) (2007 - present). |
Prof. L. Dicks |
Microbiology, SU |
Bacteriocins as a possible method to treat M. tuberculosis infection (2007-present). One publication in J. Appl. Microbiol. 2007. |
Prof. S. Mehtar |
Unit for Infection Control, Tygerberg Hospital |
The anti microbial activity of copper and copper alloys against nosocomial pathogens and M. tuberculosis isolated from healthcare facilities in the Western Cape– an in-vitro study. One publication in J. Hosp. Inf. 2008. |
Prof. Kelly Chibale |
Dept Chemistry
University of Cape Town |
Screen antituberculosis lead compounds |
Dr Thavi Govender |
Dept. Chemistry, UKZN |
Test antituberculosis activity of existing antituberculosis drug derivatives. K. Onajole 2009 |
Prof Green |
Dept Chemistry, UWC |
Screen new compounds and derivatives for antituberculosis activity |
Dr. S. Todorov |
Univ. Sao Paulo, Brazil |
Antituberculosis activity of Bacteriocins (Todorov, 2008) |
Dr C. Kenyon |
CSIR, Pretoria |
Dormancy regulators of M.tb in human macrophages. |
Dr. Haynes |
Hong Kong University of Technology |
Testing new compounds for antituberculosis activity |
Prof Peter Folb |
Pharmacology, UCT |
Testing derivatives of Diphenyl Oxazole for antituberculosis activity |
Ms. Marlein Bosman |
NHLS , Green point |
Collaborator on all our projects – provides routine samples. |
Dr. Sias May |
TB Control program in Suidkaap/ Lawwaaikamp |
TB Control strategy. |
Dr. Danie Theron |
Eben donges Hosp, Worcester |
New project on DOTS program on farms. |
Dr Else Marais |
Wits/NHLS |
Ongoing collaboration on the molecular epidemiology of drug resistant TB in Gauteng. |
Prof C. Reinecke & Dr du Toit Loots |
North West University |
New collaboration on the M.tuberculosis metabolome. |
Prof C Wright |
NHLS Tygerberg |
The diagnostic utility of FNAB |
Dr. Alistair Calver |
Gold Mine in Northern province |
Ongoing, outbreak of drug resistance in a setting with a good control program. |
Prof. Willem Hanekom |
IIDMM, UCT |
Sharing of technology (multicolour FACS, Luminex machine), sharing of samples, manuscript accepted for publication. |
Prof. Frank Brombacher |
IIDMM, UCT |
Sharing of expertise (murine helminth models). |
Dr A. Hesseling |
SU |
New collaboration to investigate genotype-immunological phenotype correlations in children. |
Dr Cahal Seioghe, and team |
NBN node, Cape Town |
New collaboration. Analysis of whole-genome sequence data. |
Mrs. Lungi Kwitshana |
MRC, Durban |
Collaboration in project on worm-HIV co-infection. |
Prof. Keertan Dheda |
Lung Institute, UCT |
Collaboration in diagnostic/biomarker project.
Molecular epidemiology of XDR-TB |
Dr. Anna Mandalakas |
Case Western Reserve University, USA |
Collaboration of diagnostic studies in paediatric TB. |
Dr. Marc Jacobsen |
Bernhard Nocht Insitute, Hamburg, Germany |
Collaboration on helminth/TB co-infection studies. |
Dr Muazzam Jacobs |
University of Cape Town |
New collaboration to assess the impact of steroid hormones on protective immunity to Mycobacterium tuberculosis in a mouse animal model. |